Diabetes Centre, Second Department of Internal Medicine, Democritus University of Thrace, Alexandroupolis, Greece.
Department of Clinical Biochemistry, Royal Free Hospital Campus, University College London Medical School, University College London (UCL), London, UK.
Curr Opin Cardiol. 2019 Jul;34(4):390-398. doi: 10.1097/HCO.0000000000000624.
To critically review the literature describing links between mean platelet volume (MPV) and cardiovascular disease (CVD). We will focus on coronary artery disease (CAD). The MPV is measured routinely as part of a routine blood count.
There is accumulating evidence showing that the MPV may predict CVD, as well as outcomes in patients with CAD. There is also evidence linking MPV and comorbidities (e.g. diabetes mellitus and impaired glycaemic control) that are expected in patients with CAD. The effect on MPV of drugs commonly used to treat CAD has not been clarified, but there is some evidence that they may exert a beneficial effect on the MPV. More specifically, the MPV may predict the effect of antiplatelet drugs (e.g. clopidogrel). There is also evidence relating MPV to stroke, atrial fibrillation, coronary artery ectasia and periprocedural outcomes after percutaneous coronary intervention (PCI).
Measuring the MPV may prove useful in CVD risk assessment in patients with established CAD or at risk of developing CAD. Overall, there is evidence pointing to the role of MPV as a contributor rather than simple marker of CVD.
批判性地回顾描述平均血小板体积（MPV）与心血管疾病（CVD）之间联系的文献。我们将重点关注冠状动脉疾病（CAD）。MPV 作为常规血液计数的一部分常规测量。
越来越多的证据表明，MPV 可预测 CVD 以及 CAD 患者的预后。还有证据表明，MPV 与 CAD 患者预期的合并症（如糖尿病和血糖控制受损）有关。常用于治疗 CAD 的药物对 MPV 的影响尚未阐明，但有一些证据表明它们可能对 MPV 产生有益影响。更具体地说，MPV 可预测抗血小板药物（如氯吡格雷）的疗效。还有证据表明，MPV 与中风、心房颤动、冠状动脉扩张以及经皮冠状动脉介入治疗（PCI）后的围手术期结局有关。
在患有已确诊 CAD 或有发生 CAD 风险的患者中，测量 MPV 可能有助于评估 CVD 风险。总体而言，有证据表明 MPV 是 CVD 的一个促成因素，而不仅仅是 CVD 的简单标志物。
