Mu Hongna, Wang Xinyue, Zhao Xianghui, Yang Ruiyue, Zhang Wenduo, Li Hongxia, Wang Siming, Ji Fusui, Chen Wenxiang, Dong Jun, Yu Xue
The Key Laboratory of Geriatrics, Beijing Institute of Geriatrics, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing Hospital/National Center of Gerontology of National Health Commission, P.R. China.
Department of Cardiology, Beijing Hospital, National Center of Gerontology; Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, P. R. China.
Int J Med Sci. 2025 Mar 24;22(8):1924-1935. doi: 10.7150/ijms.104118. eCollection 2025.
Hematological parameters are among the most accessible and routinely performed clinical tests. Recent studies have gradually revealed their potential for risk prediction. This study aimed to assess the association between hematological parameters and major adverse cardiovascular events (MACEs) in patients with coronary artery disease. This prospective study included 2,970 Chinese participants who underwent coronary angiography, with hematological and biochemical indicators measured at baseline. MACEs, comprising myocardial infarction, stroke, revascularization, and all-cause mortality, were recorded during follow-up. Univariate and multivariate analyses were conducted to evaluate the relationship between the hematological parameters and MACEs. Over a median follow-up period of 79 months, 474 MACEs were documented. Kaplan-Meier analysis indicated that the participants with lower levels of RBC, PLT, PCT, LYMPH% and BASO%, as well as higher RDW-CV, RDW-SD, MONO% and NEUT%, exhibited reduced survival probability. Multivariate Cox regression analysis identified elevated RDW-CV as a significant risk factor for MACE (T3 HR, 1.292; 95% CI, 1.013-1.647; =0.039), while lower BASO% demonstrated a protective effect (T3 HR, 0.750, 95 % CI: 0.591-0.953; =0.018). LYMPH% also showed a significant association with MACEs. Additionally, nonlinear correlations were observed between PLT and PCT and MACEs. In conclusion, RDW-CV, BASO%, PLT, PCT and LYMPH% were closely associated with MACEs and may serve as potential predictors for cardiovascular risk in patients with coronary artery disease.
血液学参数是最容易获取且常规进行的临床检查项目之一。近期研究逐渐揭示了它们在风险预测方面的潜力。本研究旨在评估冠心病患者血液学参数与主要不良心血管事件（MACE）之间的关联。这项前瞻性研究纳入了2970名接受冠状动脉造影的中国参与者，在基线时测量了血液学和生化指标。随访期间记录了包括心肌梗死、中风、血运重建和全因死亡率在内的MACE。进行单因素和多因素分析以评估血液学参数与MACE之间的关系。在中位随访期79个月内，记录了474例MACE。Kaplan-Meier分析表明，红细胞（RBC）、血小板（PLT）、血小板压积（PCT）、淋巴细胞百分比（LYMPH%）和嗜碱性粒细胞百分比（BASO%）水平较低，以及红细胞分布宽度变异系数（RDW-CV）、红细胞分布宽度标准差（RDW-SD）、单核细胞百分比（MONO%）和中性粒细胞百分比（NEUT%）较高的参与者，生存概率降低。多因素Cox回归分析确定升高的RDW-CV是MACE的显著危险因素（T3风险比[HR]，1.292；95%置信区间[CI]，1.013 - 1.647；P = 0.039），而较低的BASO%显示出保护作用（T3 HR，0.750，95% CI：0.591 - 0.953；P = 0.018）。LYMPH%也与MACE有显著关联。此外，观察到PLT和PCT与MACE之间存在非线性相关性。总之，RDW-CV、BASO%、PLT、PCT和LYMPH%与MACE密切相关，可能作为冠心病患者心血管风险的潜在预测指标。
