移植后排斥反应中是否存在天然抗体的作用？
Is There a Role for Natural Antibodies in Rejection Following Transplantation?
机构信息
Columbia Center for Translational Immunology, Columbia University Medical Center, New York, NY.
出版信息
Transplantation. 2019 Aug;103(8):1612-1619. doi: 10.1097/TP.0000000000002743.
Abstract
Antibody-mediated rejection continues to hinder long-term survival of solid organ allografts. Natural antibodies (Nabs) with polyreactive and autoreactive properties have recently emerged as potential contributors to antibody-mediated graft rejection. This review discusses Nabs, their functions in health and disease, their significance in rejection following kidney, heart, and lung transplantation, and their implication in serum reactivity to key antigens associated with rejection. Finally, potential effector mechanisms of Nabs in the context of transplantation are explored.
摘要
抗体介导的排斥反应持续阻碍实体器官移植物的长期存活。具有多反应性和自身反应性的天然抗体（Nabs）最近被认为是导致抗体介导的移植物排斥反应的潜在因素。本文综述了 Nabs 的特性、功能，以及其在肾、心、肺移植后排斥反应中的作用和对与排斥反应相关的关键抗原血清反应性的影响。最后，探讨了 Nabs 在移植背景下的潜在效应机制。
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