Departments of Pediatric Oncology.
Pathology, Regional Cancer Centre, Trivandrum, Kerala, India.
J Pediatr Hematol Oncol. 2020 Jul;42(5):e369-e372. doi: 10.1097/MPH.0000000000001472.
Primary mediastinal (thymic) large B-cell lymphoma is an aggressive B-cell lymphoma. It comprises <3% of all pediatric non-Hodgkin lymphomas (NHLs). Primary mediastinal (thymic) large B-cell lymphoma usually presents with serous pleural effusion, but presentation with chylous pleural and pericardial effusions is rare. We present a child who presented with features of a superior mediastinal syndrome. Biopsy of the mediastinal mass confirmed the diagnosis of large B-cell lymphoma. In view of nonimprovement of respiratory distress with chemotherapy and persistence of features of superior mediastinal syndrome, the child was evaluated and found to have massive pleural and pericardial effusion on imaging. Therapeutic thoracentesis and pericardiocentesis revealed chylous nature of the fluid.
原发性纵隔（胸腺）大 B 细胞淋巴瘤是一种侵袭性 B 细胞淋巴瘤。它占所有儿科非霍奇金淋巴瘤（NHL）的<3%。原发性纵隔（胸腺）大 B 细胞淋巴瘤通常表现为浆液性胸腔积液，但乳糜性胸腔和心包积液的表现较为罕见。我们报告了一例表现为纵隔综合征特征的患儿。纵隔肿块活检证实了大 B 细胞淋巴瘤的诊断。鉴于化疗未能改善呼吸窘迫，且纵隔综合征的特征持续存在，对患儿进行评估后发现影像学上存在大量胸腔和心包积液。治疗性胸腔穿刺和心包穿刺显示液体为乳糜性。
