Torres-Martínez Ana, Angulo-Pachón César A, Galindo Francisco, Miravet Juan F
Departament de Química Inorgànica i Orgànica, Universitat Jaume I, Avda. Sos Baynat s/n, 12071 Castelló, Spain.
Soft Matter. 2019 Apr 24;15(17):3565-3572. doi: 10.1039/c9sm00252a.
The preparation of molecular, non-polymeric nanogels from a low molecular weight hydrogelator is reported. The molecular nanogels are expected to overcome issues associated with the use of polymeric nanogels in biomedicine such as biodegradability, stimuli responsiveness, polydispersity, and batch-to-batch reproducibility. Nanogels formed by compound 1 were reproducibly prepared by sonication of a xerogel in PBS, with a total concentration of ca. 2 mM. The intensity averaged diameter of ca. 200 nm was determined by DLS. Electron microscopy (TEM and cryo-TEM) showed spherical particles. Light scattering (SALS) indicates that water is the main component of the nanoparticles, and the concentration of 1 in the nanogels is ca. 3 mg mL-1. These particles can be considered to constitute an intermediate state between free molecules and self-assembled fibrillar networks. The nanogels present excellent temporal and thermal stability and accessible hydrophobic domains, as demonstrated by the incorporation of the fluorescent dye Nile Red.
报道了由低分子量水凝胶剂制备分子型非聚合纳米凝胶的方法。分子纳米凝胶有望克服在生物医学中使用聚合纳米凝胶时出现的问题，如生物降解性、刺激响应性、多分散性和批次间重现性。通过在PBS中超声处理干凝胶可重复制备由化合物1形成的纳米凝胶，总浓度约为2 mM。通过动态光散射（DLS）测定平均强度直径约为200 nm。电子显微镜（透射电子显微镜和冷冻透射电子显微镜）显示为球形颗粒。光散射（小角光散射）表明水是纳米颗粒的主要成分，纳米凝胶中1的浓度约为3 mg mL-1。这些颗粒可被视为构成了自由分子和自组装纤维状网络之间的中间状态。如通过掺入荧光染料尼罗红所证明的，纳米凝胶具有出色的时间和热稳定性以及可及的疏水区域。
