Departament de Química Inorgànica i Orgànica, Universitat Jaume I , Avda. Sos Baynat s/n, 12071 Castellón, Spain.
Langmuir. 2017 Oct 3;33(39):10322-10328. doi: 10.1021/acs.langmuir.7b02440. Epub 2017 Sep 25.
A low molecular weight gelator with a fluorescent 1,8-naphthalimide unit forms micro- and nanoparticles in aqueous media. Slow addition of a DMSO solution of the gelator into water affords either a self-assembled fibrillar network, sheaf-like microparticles, or nanoparticles depending to the concentration used in the experiment. The micro- and nanoparticles were characterized by dynamic light scattering (DLS), electron microscopy, and fluorescence measurements. In an initial assay of particle loading, Rose Bengal and Rhodamine 123 were shown to be incorporated in the particles. Light-promoted singlet oxygen generation capabilities of Rose Bengal were modulated by its incorporation in the particles. Additionally, the particles were found to promote the transport of Rhodamine 123 into human lung carcinoma live cells. These results indicate that nanoparticles arising from low molecular weight gelators may represent a new type of nanocarriers, being a potential alternative to polymeric nanogels used in nanomedicine.
一种具有荧光 1,8-萘酰亚胺单元的低分子量凝胶剂在水介质中形成微球和纳米颗粒。将凝胶剂的 DMSO 溶液缓慢加入水中，根据实验中使用的浓度，可以得到自组装的纤维状网络、束状微粒或纳米颗粒。通过动态光散射（DLS）、电子显微镜和荧光测量对微球和纳米颗粒进行了表征。在初步的粒子负载测定中，发现孟加拉玫瑰红和罗丹明 123 被包裹在粒子中。罗丹明 123 的光促进单线态氧生成能力通过其在粒子中的掺入得到了调节。此外，还发现这些粒子能促进罗丹明 123 进入人肺癌活细胞的转运。这些结果表明，低分子量凝胶剂产生的纳米颗粒可能代表一种新型的纳米载体，是纳米医学中使用的聚合物纳米凝胶的潜在替代品。
