通过 Morita-Baylis-Hillman 加合物与不饱和砜的碱介导的[3+3]苯并环化反应，简便合成二芳基甲烷和四取代芳烃。
Facile synthesis of biarylmethanes and tetrasubstituted arenes via a base-mediated [3 + 3] benzannulation reaction of Morita-Baylis-Hillman adducts and unsaturated sulfones.
机构信息
Department of Chemistry, Central University of Haryana, Mahendergarh, Haryana 123029, India.
出版信息
Org Biomol Chem. 2019 Apr 17;17(16):4073-4076. doi: 10.1039/c9ob00214f.
PMID:30951081
Abstract
A facile DBU-mediated [3 + 3] benzannulation reaction of 1,3-bis-sulfonyl propenes and Morita-Baylis-Hillman (MBH) bromides is described. The benzannulation reaction afforded bis-sulfonyl biarylmethanes/arenes with complete regioselectivity. The products may be converted readily into corresponding benzophenones via site-selective benzylic oxidation.
摘要
一种简便的 DBU 介导的 1,3-双砜基丙烯和 Morita-Baylis-Hillman（MBH）溴化物的[3+3]苯并环化反应被描述。苯并环化反应以完全区域选择性得到双砜基联苯甲烷/芳烃。通过选择性苄基氧化，产物可以很容易地转化为相应的二苯甲酮。
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