直接构建多官能化苯环：α-氰基-β-亚甲基酮与α,β-不饱和醛的[4 + 2]环化反应
Direct access to multi-functionalized benzenes [4 + 2] annulation of α-cyano-β-methylenones and α,β-unsaturated aldehydes.
作者信息
Jia Qianfa, Lan Yunfei, Ye Xin, Lin Yinhe, Ren Qiao
机构信息
Chongqing Key Laboratory of Inorganic Special Functional Materials, College of Chemistry and Chemical Engineering, Yangtze Normal University Fuling Chongqing 408100 P. R. China.
College of Pharmaceutical Science, Southwest University Chongqing 400715 P. R. China.
出版信息
RSC Adv. 2020 Aug 6;10(49):29171-29174. doi: 10.1039/d0ra05251e. eCollection 2020 Aug 5.
Abstract
An efficient [4 + 2] benzannulation of α-cyano-β-methylenones and α,β-unsaturated aldehydes was achieved under metal-free reaction conditions selectively delivering a wide range of polyfunctional benzenes in high yields respectively (up to 94% yield).
摘要
在无金属反应条件下，实现了α-氰基-β-亚甲基酮与α,β-不饱和醛的高效[4 + 2]苯并环化反应，分别以高收率（高达94%）选择性地生成了多种多官能团苯。
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