Udo Edet Ekpenyong, Boswihi Samar Saed, Dimitrov Tsonyu Ivanov, Noronha Bobby, Mathew Bindu, Verghese Tina
Health Sciences Centre, Kuwait University, Kuwait, Kuwait.
Infectious Disease Hospital, Kuwait, Kuwait.
J Infect Dev Ctries. 2017 Jun 27;11(6):513-516. doi: 10.3855/jidc.8954.
The isolation of a rare community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA) strain from an infected dog bite wound is here reported. A 27-year old man presented with a deep open wound on his right hand caused by his dog's bite at the outpatient clinic of Infectious Disease Hospital (IDH), Kuwait. A wound swab was obtained for bacteriological culture and susceptibility testing. The wound culture yielded pure heavy growth of an MRSA isolate, designated IDH70, which was susceptible to vancomycin, teicoplanin, erythromycin, clindamycin, trimethoprim, fusidic acid and rifampicin. The patient was successfully treated with a combination of rifampicin and cotrimoxazole twice daily for 10 days. Molecular characterization revealed that IDH70 was positive for genes encoding Panton-Valentine leucocidin. IDH70 also carried the SCCmec V genetic element, belonged to coagulase type XIIIa, spa type t903, and was assigned to clonal complex 1153 and sequence type ST1153 (ST1153-V-t903). The report highlights the increasing burden of CA-MRSA in the community and the risk of its acquisition from bites of companion animals.
本文报道了从一例感染的犬咬伤伤口中分离出一株罕见的社区获得性耐甲氧西林金黄色葡萄球菌（CA-MRSA）。一名27岁男性因被其宠物狗咬伤，在科威特传染病医院（IDH）门诊就诊时右手出现深部开放性伤口。采集伤口拭子进行细菌培养和药敏试验。伤口培养物中分离出一株纯的MRSA菌株，命名为IDH70，该菌株对万古霉素、替考拉宁、红霉素、克林霉素、甲氧苄啶、夫西地酸和利福平敏感。患者接受利福平和复方新诺明联合治疗，每日两次，持续10天，治疗成功。分子特征分析显示，IDH70编码杀白细胞素的基因呈阳性。IDH70还携带SCCmec V基因元件，属于凝固酶 XIIIa型，spa型t903，被归类为克隆复合体1153和序列型ST1153（ST1153-V-t903）。该报告强调了社区中CA-MRSA负担的增加以及从伴侣动物咬伤中获得感染的风险。
