夜空中的星辰：诱导多能干细胞心肌细胞将患者背景信息带回药物筛选。
Stars in the Night Sky: iPSC-Cardiomyocytes Return the Patient Context to Drug Screening.
机构信息
Stanford Cardiovascular Institute and Department of Medicine, Stanford University, 1651 Page Mill Road, Palo Alto, CA 94305, USA.
Stanford Cardiovascular Institute and Department of Medicine, Stanford University, 1651 Page Mill Road, Palo Alto, CA 94305, USA.
出版信息
Cell Stem Cell. 2019 Apr 4;24(4):506-507. doi: 10.1016/j.stem.2019.03.013.
iPSC-derived cardiomyocytes have the potential to revolutionize the discovery of new medicines for serious heart conditions; however, heart failure remains a major cause of mortality worldwide. In this issue of Cell Stem Cell, Fiedler et al. (2019) describe using iPSC-derived cardiomyocytes to screen new chemical entities, discovering a small molecule for ischemic injury.
iPSC 分化而来的心肌细胞有望为严重心脏疾病的新药研发带来革命性的变化；然而，心力衰竭仍然是全球范围内主要的致死原因。在本期的《Cell Stem Cell》杂志上，Fiedler 等人（2019）描述了使用 iPSC 分化而来的心肌细胞进行新型化学物质的筛选，发现了一种针对缺血性损伤的小分子。
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