The Second Affiliated Hospital, School of Pharmacy, Dalian Medical University, Dalian, Liaoning, China (J. Q., J. G.); The First Affiliated Hospital, School of Pharmacy, Anhui Medical University, Hefei, Anhui, China (J.Q., J.G.); Department of Orthopedics, Warren Alpert Medical School, Brown University/Rhode Island Hospital, Providence, Rhode Island (L.Y.); and Department of Molecular Biology, Cell Biology and Biochemistry, Brown University Division of Biology and Medicine, Providence, Rhode Island (H.Y.).
The Second Affiliated Hospital, School of Pharmacy, Dalian Medical University, Dalian, Liaoning, China (J. Q., J. G.); The First Affiliated Hospital, School of Pharmacy, Anhui Medical University, Hefei, Anhui, China (J.Q., J.G.); Department of Orthopedics, Warren Alpert Medical School, Brown University/Rhode Island Hospital, Providence, Rhode Island (L.Y.); and Department of Molecular Biology, Cell Biology and Biochemistry, Brown University Division of Biology and Medicine, Providence, Rhode Island (H.Y.)
J Pharmacol Exp Ther. 2019 Jun;369(3):473-480. doi: 10.1124/jpet.118.256222. Epub 2019 Apr 5.
Chronic obstructive pulmonary disease (COPD) is a chronic lung disease with progressive airflow limitation and functional decline. The pathogenic mechanisms for this disease include oxidative stress, inflammatory responses, disturbed protease/antiprotease equilibrium, apoptosis/proliferation imbalance, senescence, autophagy, metabolic reprogramming, and mitochondrial dysfunction. The Wnt signaling pathway is an evolutionarily conserved signaling pathway that is abnormal in COPD, including chronic bronchitis and pulmonary emphysema. Furthermore, Wnt signaling has been shown to modulate aforementioned cellular processes involved in COPD. From this perspective, we provide an updated understanding of the crosstalk between Wnt signal and these cellular processes, and highlight the crucial role of the Wnt signal during the development of COPD. We also discuss the potential for targeting the Wnt signal in future translational and pharmacological therapeutics aimed at prevention and treatment of this disease.
慢性阻塞性肺疾病（COPD）是一种慢性肺部疾病，具有进行性气流受限和功能下降。该疾病的发病机制包括氧化应激、炎症反应、蛋白酶/抗蛋白酶平衡紊乱、细胞凋亡/增殖失衡、衰老、自噬、代谢重编程和线粒体功能障碍。Wnt 信号通路是一种进化上保守的信号通路，在 COPD 中异常，包括慢性支气管炎和肺气肿。此外，Wnt 信号已被证明可以调节 COPD 中涉及的上述细胞过程。从这个角度来看，我们提供了对 Wnt 信号与这些细胞过程之间相互作用的最新理解，并强调了 Wnt 信号在 COPD 发展过程中的关键作用。我们还讨论了针对 Wnt 信号在未来针对这种疾病的预防和治疗的转化和药理学治疗中的潜在应用。
