Weifang Medical University, Weifang, Shandong, China.
PeerJ. 2024 Jul 8;12:e17662. doi: 10.7717/peerj.17662. eCollection 2024.
miRNAs are small, conserved, single-stranded non-coding RNA that are typically transported by exosomes for their functional roles. The therapeutic potential of exosomal miRNAs has been explored in various diseases including breast cancer, pancreatic cancer, cholangiocarcinoma, skin diseases, Alzheimer's disease, stroke, and glioma. Pathophysiological processes such as cellular inflammation, apoptosis, necrosis, immune dysfunction, and oxidative stress are closely associated with miRNAs. Internal and external factors such as tissue ischemia, hypoxia, pathogen infection, and endotoxin exposure can trigger these reactions and are linked to miRNAs. Paraquat-induced fibrosis is a protracted process that may not manifest immediately after injury but develops during bodily recovery, providing insights into potential miRNA intervention treatments.
These findings could potentially be applied for further pharmaceutical research and clinical therapy of paraquat-induced pulmonary fibrosis, and are likely to be of great interest to clinicians involved in lung fibrosis research.
Through a literature review, we identified an association between miR-15a-5p and miR-152-3p and their involvement in the Wnt signaling pathway. This allowed us to deduce the molecular mechanisms underlying regulatory interactions involved in paraquat-induced lung fibrosis.
miR-15a-5p and miR-152-3p play roles in body repair processes, and pulmonary fibrosis can be considered a form of reparative response by the body. Although the initial purpose of fibrotic repair is to restore normal body function, excessive tissue fibrosis, unlike scar formation following external skin trauma, can significantly and adversely affect the body. Modulating the Wnt/β-catenin signaling pathway is beneficial in alleviating tissue fibrosis in various diseases.
In this study, we delineate the association between miR-15a-5p and miR-152-3p and the Wnt/β-catenin signaling pathway, presenting a novel concept for addressing paraquat-induced pulmonary fibrosis.
miRNA 是一种小型、保守的单链非编码 RNA，通常通过外泌体运输以发挥其功能。外泌体 miRNA 的治疗潜力已在多种疾病中得到探索，包括乳腺癌、胰腺癌、胆管癌、皮肤病、阿尔茨海默病、中风和神经胶质瘤。细胞炎症、细胞凋亡、细胞坏死、免疫功能障碍和氧化应激等病理生理过程与 miRNA 密切相关。组织缺血、缺氧、病原体感染和内毒素暴露等内外因素可引发这些反应，并与 miRNA 有关。百草枯诱导的纤维化是一个漫长的过程，损伤后可能不会立即表现出来，而是在身体恢复过程中发展，为潜在的 miRNA 干预治疗提供了思路。
这些发现可能为百草枯诱导的肺纤维化的进一步药物研究和临床治疗提供参考，并且可能会引起从事肺纤维化研究的临床医生的极大兴趣。
通过文献回顾，我们发现 miR-15a-5p 和 miR-152-3p 与 Wnt 信号通路有关，并推断出百草枯诱导肺纤维化中调节相互作用的分子机制。
miR-15a-5p 和 miR-152-3p 在机体修复过程中发挥作用，肺纤维化可以被视为机体的一种修复反应。虽然纤维化修复的最初目的是恢复正常的身体功能，但与外伤后皮肤形成的疤痕不同，过度的组织纤维化会对身体造成显著且不利的影响。调节 Wnt/β-catenin 信号通路有助于缓解各种疾病中的组织纤维化。
在这项研究中，我们描述了 miR-15a-5p 和 miR-152-3p 与 Wnt/β-catenin 信号通路之间的关联，为解决百草枯诱导的肺纤维化提供了一个新的概念。
