洁白无瑕的循环永放光芒。

Eternal sunshine of the spotless cycle.

机构信息

Laboratory of Dynamics in Biological Systems, Department of Cellular and Molecular Medicine, University of Leuven, Leuven, Belgium.

Quantitative Cell Biology Laboratory, The Francis Crick Institute, London, UK.

出版信息

Mol Syst Biol. 2019 Apr 5;15(4):e8864. doi: 10.15252/msb.20198864.

DOI:10.15252/msb.20198864

PMID:30952682

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6449696/

Abstract

Understanding the quantitative principles underlying the durations of each of the four cell cycle phases has remained a challenge, despite the extensive knowledge on the molecular components and mechanisms related to cell cycle control. In their recent study, Purvis and colleagues (Chao , 2019) quantify cell cycle phase durations in human cells and propose a model whereby cell cycle progression in single cells is a succession of uncoupled, memoryless phases, each composed of a characteristic rate and number of steps.

摘要

尽管人们对与细胞周期控制相关的分子成分和机制有了广泛的了解，但要理解四个细胞周期阶段的持续时间所依据的定量原理仍然是一个挑战。在他们最近的研究中，Purvis 及其同事（Chao ，2019）对人类细胞的细胞周期阶段持续时间进行了量化，并提出了一个模型，即单细胞中的细胞周期进展是一系列不相关的、无记忆的阶段的连续，每个阶段都由一个特征速率和步骤数组成。