Hunt F C, Maddalena D J, Wilson J G, Bautovich G J
Int J Rad Appl Instrum B. 1986;13(3):289-93. doi: 10.1016/0883-2897(86)90111-x.
A series of alkyl- and halogen-substituted derivatives of ethylenediamine di[o-hydroxyphenylacetic acid] (EDDHA) and N,N'-bis[2-hydroxybenzyl] ethylenediamine N,N'-diacetic acid (HBED) were complexed with 99mTc and their biodistribution was determined in rats. All complexes displayed substantial hepatobiliary excretion; of each series, 99mTc-Br-EDDHA and 99mTc-di-Cl-HBED had the maximum amount in the gastrointestinal tract. Scintigraphic studies of 99mTc-Cl-EDDHA in dogs revealed prompt imaging of the liver followed by imaging of the gall bladder as the complex was excreted into the bile.
一系列乙二胺二[邻羟基苯乙酸]（EDDHA）和N，N'-双[2-羟基苄基]乙二胺N，N'-二乙酸（HBED）的烷基和卤素取代衍生物与99mTc络合，并在大鼠中测定了它们的生物分布。所有络合物都表现出大量的肝胆排泄；在每个系列中，99mTc-Br-EDDHA和99mTc-二-Cl-HBED在胃肠道中的含量最高。对犬进行的99mTc-Cl-EDDHA闪烁扫描研究显示，随着络合物排入胆汁，肝脏迅速显影，随后胆囊显影。
