使用兔模型对用于血栓成像的放射性标记剂进行比较。

A comparison of radiolabelled agents for thrombus imaging using a rabbit model.

作者信息

Campbell J, Bellen J C, Baker R J, McLaren A B

出版信息

Int J Rad Appl Instrum B. 1986;13(3):295-300. doi: 10.1016/0883-2897(86)90112-1.

Abstract

The quantitative uptakes of five potential thrombus-localizing radiopharmaceuticals in experimental thrombi of the rabbit jugular vein have been compared to assist with the selection of a thrombus imaging agent for clinical use. Three hours after injection, 111In-platelets were clearly the agent of choice but at 18 h 99mTc-fibrinogen had more favourable characteristics. Both agents were superior to 99mTc-plasmin or its acyl derivatives, including 99mTc-streptokinase-activated anisoylplasminogen. The ease of preparation coupled with favourable biological properties suggest that 99mTc-fibrinogen should be of value in the clinical situation.

摘要

为了帮助选择一种用于临床的血栓显像剂，对五种潜在的血栓定位放射性药物在兔颈静脉实验性血栓中的定量摄取进行了比较。注射后三小时，111铟标记的血小板显然是首选药物，但在18小时时，99m锝标记的纤维蛋白原具有更有利的特性。这两种药物均优于99m锝标记的纤溶酶或其酰基衍生物，包括99m锝标记的链激酶激活的茴香酰纤溶酶原。制备简便且具有良好的生物学特性表明，99m锝标记的纤维蛋白原在临床应用中应具有价值。