DE Paz Dante, Young Chi-Kuang, Chien Huei-Tzu, Tsao Chung-Kang, Fok Cheong Chon, Fan Kang-Hsing, Liao Chun-Ta, Wang Hung-Ming, Kang Chung-Jan, Chang Joseph Tung-Chieh, Huang Shiang-Fu
Department of Otolaryngology - Head & Neck Surgery, Chang Gung Memorial Hospital, Taoyuan, Taiwan, R.O.C.
Department of Head and Neck Surgery, San Pedro University, San Pedro, Peru.
Anticancer Res. 2019 Apr;39(4):2025-2033. doi: 10.21873/anticanres.13313.
BACKGROUND/AIM: Tumor-related and inflammation-related markers were reported to be prognostic in cancer patients. In this study, we evaluated squamous cell carcinoma antigen (SCC-Ag), cytokeratin 19 fragment (CYFRA 21-1) and C-reactive protein (CRP) simultaneously in oral cavity squamous cell carcinoma (OSCC) patients.
Two hundred and forty-six newly diagnosed OSCC patients were retrospectively recruited between December 2010 and December 2016.
The elevation of CRP levels (≥5.0 mg/l) and SCC-Ag levels (≥2.0 ng/ml) were significantly related with tumor invasion parameters and metastatic factors. In contrast, the elevation of CYFRA 21-1 levels (≥3.3 ng/ml) was related with extranodal extension alone. For patients with all three markers being elevated before surgery, their overall survival and disease-free survival were significantly worse than others.
Concurrent elevation of preoperative SCC-Ag, CYFRA 21-1 and CRP serum levels can be correlated with worse survival rates in OSCC.
背景/目的：据报道，肿瘤相关标志物和炎症相关标志物对癌症患者具有预后价值。在本研究中，我们同时评估了口腔鳞状细胞癌（OSCC）患者的鳞状细胞癌抗原（SCC-Ag）、细胞角蛋白19片段（CYFRA 21-1）和C反应蛋白（CRP）。
回顾性纳入2010年12月至2016年12月期间新诊断的246例OSCC患者。
CRP水平升高（≥5.0mg/l）和SCC-Ag水平升高（≥2.0ng/ml）与肿瘤侵袭参数和转移因素显著相关。相比之下，CYFRA 21-1水平升高（≥3.3ng/ml）仅与结外扩展有关。对于术前所有三种标志物均升高的患者，其总生存期和无病生存期明显差于其他患者。
术前SCC-Ag、CYFRA 21-1和CRP血清水平同时升高与OSCC患者较差的生存率相关。
