小胆管型和胆管细管型肝内胆管癌临床病理特征的比较
Comparison of the Clinicopathological Features in Small Bile Duct and Bile Ductular Type Intrahepatic Cholangiocarcinoma.
作者信息
Yamada Mihoko, Yamamoto Yusuke, Sugiura Teiichi, Kakuda Yuko, Ashida Ryo, Tamura Shunsuke, Okamura Yukiyasu, Ito Takaaki, Ohgi Katsuhisa, Nakanuma Yasuni, Uesaka Katsuhiko
机构信息
Division of Hepato-Biliary-Pancreatic Surgery, Shizuoka Cancer Center, Shizuoka, Japan.
Division of Hepato-Biliary-Pancreatic Surgery, Shizuoka Cancer Center, Shizuoka, Japan
出版信息
Anticancer Res. 2019 Apr;39(4):2121-2127. doi: 10.21873/anticanres.13325.
BACKGROUND
The classification of intrahepatic cholangiocarcinomas (ICCs) has been reported in several studies, however, it remains controversial.
MATERIALS AND METHODS
Between January 2003 and December 2015, 94 patients underwent hepatectomy for ICC. The ICCs of 63 of these patients were classified as predominantly small bile duct type or bile ductular type ICC and were included in this analysis.
RESULTS
Thirty-seven patients (58.7%) were classified into the small bile duct ICC group, and 26 (41.3%) into the bile ductular ICC group. A multivariate analysis identified intrahepatic metastasis [hazard ratio (HR)=2.53, p=0.011], small bile duct ICC (HR=2.05, p=0.046) and portal vein invasion (HR 2.05, p=0.047) as independent prognostic factors for poorer survival.
CONCLUSION
It is important to correctly distinguish between small bile duct and bile ductular ICC types because these two types clearly have different clinicopathological and prognostic features.
背景
多项研究报道了肝内胆管癌（ICC）的分类，但仍存在争议。
材料与方法
2003年1月至2015年12月期间，94例患者因ICC接受肝切除术。其中63例患者的ICC被分类为主要为小胆管型或胆管样型ICC，并纳入本分析。
结果
37例患者（58.7%）被分类为小胆管ICC组，26例（41.3%）被分类为胆管样ICC组。多因素分析确定肝内转移[风险比（HR）=2.53，p=0.011]、小胆管ICC（HR=2.05，p=0.046）和门静脉侵犯（HR 2.05，p=0.047）是生存较差的独立预后因素。
结论
正确区分小胆管型和胆管样型ICC很重要，因为这两种类型具有明显不同的临床病理和预后特征。
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