术后C反应蛋白是预测非小细胞肺癌切除术后生存的生物标志物。
Postoperative C-reactive Protein Is a Predictive Biomarker for Survival After Non-small Cell Lung Cancer Resection.
作者信息
Shinohara Shuichi, Otsuki Ryo, Onitsuka Takamitsu, Machida Kazuhiko, Matsuo Masaki, Nakagawa Makoto, Sugaya Masakazu
机构信息
Department of Thoracic Surgery, Chubu Rosai Hospital, Nagoya, Japan
Department of Pulmonary and Respiratory Medicine, Chubu Rosai Hospital, Nagoya, Japan.
出版信息
Anticancer Res. 2019 Apr;39(4):2193-2198. doi: 10.21873/anticanres.13334.
BACKGROUND/AIM: Preoperative C-reactive protein (CRP) is well recognized as a prognostic factor of non-small cell lung cancer (NSCLC). The present study aimed to elucidate the prognostic impact of postoperative CRP in patients with NSCLC following lung resection.
PATIENTS AND METHODS
We retrospectively reviewed 336 patients with NSCLC treated with lung resection. CRP levels were measured at postoperative week 6 (CRP; range: 4-8 weeks). Patients were divided into two groups based on CRP median value (5.0 mg/l); the 5-year overall survival (OS) as well as the recurrence-free survival (RFS) was evaluated in both groups.
RESULTS
Five-year OS and RFS were worse in the high-CRP group than in the low-CRP group (62.9% vs. 82.9%; p<0.001, 48.4% vs. 76.1%; p<0.001, respectively). Subgroup analysis for pathological stage I and ≥II also revealed worse OS in the high-CRP group. Multivariate analysis revealed an association between high CRP and worse OS (hazard ratio, 2.23; p<0.001).
CONCLUSION
CRP may serve as a prognostic biomarker in patients with resected NSCLC.
背景/目的：术前C反应蛋白（CRP）是公认的非小细胞肺癌（NSCLC）预后因素。本研究旨在阐明肺切除术后CRP对NSCLC患者的预后影响。
患者与方法
我们回顾性分析了336例行肺切除治疗的NSCLC患者。在术后第6周（CRP；范围：4 - 8周）测量CRP水平。根据CRP中位数（5.0mg/l）将患者分为两组；评估两组的5年总生存率（OS）以及无复发生存率（RFS）。
结果
高CRP组的5年OS和RFS低于低CRP组（分别为62.9%对82.9%；p<0.001，48.4%对76.1%；p<0.001）。对病理分期I期和≥II期的亚组分析也显示高CRP组的OS较差。多因素分析显示高CRP与较差的OS相关（风险比，2.23；p<0.001）。
结论
CRP可作为肺切除术后NSCLC患者的预后生物标志物。
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