成纤维细胞生长因子-2及其受体基因多态性对乙型肝炎病毒相关性肝细胞癌患者生存的影响
Effect of Fibroblast Growth Factor-2 and its Receptor Gene Polymorphisms on the Survival of Patients With Hepatitis B Virus-associated Hepatocellular Carcinoma.
作者信息
Kim Soon Sun, Eun Jung Woo, Cho Hyo Jung, Lee Hyun-Young, Seo Chul Won, Noh Choong Kyun, Shin Sung Jae, Lee Kee Myung, Cho Sung Won, Cheong Jae Youn
机构信息
Department of Gastroenterology, Ajou University School of Medicine, Suwon, Republic of Korea.
Clinical Trial Center, Ajou University Hospital, Suwon, Republic of Korea.
出版信息
Anticancer Res. 2019 Apr;39(4):2217-2226. doi: 10.21873/anticanres.13337.
BACKGROUND/AIM: Fibroblast growth factor (FGF), vascular endothelial growth factor, and hepatocyte growth factor play a critical role in the pathogenesis of hepatocellular carcinoma (HCC).
MATERIALS AND METHODS
We assessed nine single nucleotide polymorphisms (SNPs) in the FGF1, FGF2, FGF receptor (FGFR)-2, Flt-1, and c-MET genes in 245 HCC patients and 483 chronic hepatitis B virus (HBV) carriers without HCC.
RESULTS
Kaplan-Meier analysis showed that patients with the FGF2 rs308447 TT genotype had shorter overall survival than patients with the CC or CT genotype (p=0.016) and that FGF2 rs308379 A allele carriers had shorter overall survival than patients with the TT genotype (p=0.020).
CONCLUSION
Multivariate Cox proportional analysis revealed that the FGF2 rs308379 A allele (hazard ratio(HR)=1.663, p=0.004) and advanced tumor stage (HR=3.430, p<0.001) were independent prognostic factors for overall survival in patients with HCC.
背景/目的：成纤维细胞生长因子（FGF）、血管内皮生长因子和肝细胞生长因子在肝细胞癌（HCC）的发病机制中起关键作用。
材料与方法
我们评估了245例HCC患者和483例无HCC的慢性乙型肝炎病毒（HBV）携带者的FGF1、FGF2、FGF受体（FGFR）-2、Flt-1和c-MET基因中的9个单核苷酸多态性（SNP）。
结果
Kaplan-Meier分析显示，FGF2 rs308447 TT基因型患者的总生存期短于CC或CT基因型患者（p = 0.016），且FGF2 rs308379 A等位基因携带者的总生存期短于TT基因型患者（p = 0.020）。
结论
多因素Cox比例分析显示，FGF2 rs308379 A等位基因（风险比（HR）= 1.663，p = 0.004）和肿瘤晚期（HR = 3.430，p < 0.001）是HCC患者总生存期的独立预后因素。
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