Hayashi H, Takayama K
Jpn J Physiol. 1978;28(3):333-45. doi: 10.2170/jjphysiol.28.333.
The effect of stimulation of the vagaosympathetic trunk or the vagal nerve on the cardiac interval of the spontaneously beating heart of the bullfrog was studied in the presence and absence of Cd. The prolongation of the cardiac interval following the nerve stimulation was abolished by Cd (5 micrometer). Such an effect of Cd was completely antagonized by increasing the external Ca to 10 times the normal concentration. Cd (10 micrometer) did not alter the compound action potential of the nerve trunk, nor did it affect the pacemaker activity of the heart. Bioassay of acetylcholine in the effluent from the heart after cardiac nerve stimulation showed that Cd reduced the acetylcholine release from the cardiac nerve. It is concluded that Cd may act on the cardiac nerve terminals where Cd suppresses the release of acetycholine.
在有和没有镉（Cd）存在的情况下，研究了刺激迷走交感干或迷走神经对牛蛙自主跳动心脏的心搏间期的影响。神经刺激后的心搏间期延长可被5微米的Cd消除。通过将细胞外钙浓度提高到正常浓度的10倍，Cd的这种作用可被完全拮抗。10微米的Cd不会改变神经干的复合动作电位，也不会影响心脏的起搏活动。对心脏神经刺激后心脏流出液中的乙酰胆碱进行生物测定表明，Cd减少了心脏神经释放的乙酰胆碱。得出的结论是，Cd可能作用于心脏神经末梢，在那里Cd抑制乙酰胆碱的释放。
