5-羟色胺对乙酰胆碱释放的突触前调节。
Presynaptic regulation of the release of acetylcholine by 5-hydroxytryptamine.
作者信息
Hirai K, Koketsu K
出版信息
Br J Pharmacol. 1980 Nov;70(3):499-500. doi: 10.1111/j.1476-5381.1980.tb08729.x.
Abstract
1 The effect of 5-hydroxytryptamine (5-HT) on the release of acetylcholine (ACh) from bullfrog sympathetic preganglionic nerve terminals and frog sciatic nerve terminals was studied with intra-cellular microelectrodes. 2 The change in transmitter release was measured from the mean quantal content calculated by the variance method from evoked fast e.p.s.ps or e.p.ps in low Ca2+-high Mg2+ Ringer solution. 3 5-HT facilitated the release of ACh in low concentrations and depressed it in relatively high concentrations at both preganglionic and motor nerve terminals. 4 These results suggest the possibility that 5-HT may play a role in regulating cholinergic transmission in general.
摘要
- 用细胞内微电极研究了5-羟色胺（5-HT）对牛蛙交感神经节前神经末梢和青蛙坐骨神经末梢乙酰胆碱（ACh）释放的影响。2. 在低钙-高镁林格液中，通过方差法从诱发的快速兴奋性突触后电位（e.p.s.ps）或兴奋性突触后电位（e.p.ps）计算出的平均量子含量来测量递质释放的变化。3. 在节前和运动神经末梢，低浓度的5-HT促进ACh释放，而相对高浓度时则抑制其释放。4. 这些结果提示5-HT可能在一般情况下对胆碱能传递起调节作用。
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