啮齿动物疟疾对黄曲霉毒素B1诱导的肝脏肿瘤形成的增强作用。
Enhancing effects of rodent malaria on aflatoxin B1-induced hepatic neoplasia.
作者信息
Angsubhakorn S, Sathiropas P, Bhamarapravati N
出版信息
J Cancer Res Clin Oncol. 1986;112(2):177-9. doi: 10.1007/BF00404403.
The interaction between aflatoxin and malaria was tested for its usefulness as a model for hepatic tumor induction in rats. Male Buffalo rats which received aflatoxin B1 (AFB1) followed by Plasmodium berghei infection developed more preneoplastic lesions in the liver compared to those given AFB1 alone. No preneoplastic lesions were found in the liver of control and malarial-treated animals. These findings suggest that the malarial parasite facilitates liver tumor development initiated by AFB1 in rats.
测试了黄曲霉毒素与疟疾之间的相互作用，以评估其作为大鼠肝肿瘤诱导模型的有效性。与仅接受黄曲霉毒素B1（AFB1）的雄性布法罗大鼠相比，先接受AFB1然后感染伯氏疟原虫的大鼠肝脏中出现了更多的癌前病变。在对照动物和接受疟疾治疗的动物肝脏中未发现癌前病变。这些发现表明，疟原虫促进了AFB1引发的大鼠肝脏肿瘤的发展。
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