Department of Laboratory Medicine, AZ Sint-Jan Brugge AV, Ruddershove 10, 8000, Bruges, Belgium.
Department of Nephrology and Infectious Diseases, AZ Sint-Jan Brugge AV, Ruddershove 10, 8000, Bruges, Belgium.
Infection. 2019 Oct;47(5):853-856. doi: 10.1007/s15010-019-01276-8. Epub 2019 Apr 5.
Coagulase-negative staphylococci (CNS) are considered to have a medium or low pathogenic capacity when compared to S. aureus. Among the more harmless, CNS are those that are used in the food industry, represented by S. carnosus, whose genome has extensively been studied. Its genome was found to contain several genomic sequences that have a virulent function in the pathogenic S. aureus. Even though these genes are probably not virulent in S. carnosus, their presence might indicate a more virulent potential. We report the third clinical case associated with a surgical-site infection with S. condimenti, which belongs to these food industry related CNS. It corresponds to a blood stream infection, secondary to a surgical-site infection.
Antibiotic susceptibility testing indicated a resistance to erythromycin and rifampicin, which was partly confirmed by the presence of a macrolide resistance gene by PCR screening for S. aureus virulence factors. Although no other putative virulence factors were detected, this organism managed to cause a severe post-operative wound infection.
This case shows that CNS that are currently used in the food industry may play a role in human infection. With technologies such as MALDI-TOF, pathogens that are regarded non-pathogenic could be identified more often. Therefore, the risk of different Staphylococcus strains used in the food industry must be better assessed.
与金黄色葡萄球菌相比，凝固酶阴性葡萄球菌（CNS）被认为具有中等或低致病性。在相对无害的 CNS 中，有一些被用于食品工业，以肉糖葡萄球菌（S. carnosus）为代表，其基因组已被广泛研究。其基因组中发现了几个具有致病性金黄色葡萄球菌毒力功能的基因组序列。尽管这些基因在肉糖葡萄球菌中可能没有毒性，但它们的存在可能表明具有更强的潜在毒性。我们报告了第三个与属于相关 CNS 的食品工业有关的手术部位感染的临床病例。它是继发于手术部位感染的血流感染。
抗生素药敏试验表明对红霉素和利福平有耐药性，通过聚合酶链反应（PCR）筛选金黄色葡萄球菌毒力因子，部分证实了存在大环内酯类耐药基因。虽然没有检测到其他潜在的毒力因子，但这种细菌还是成功地导致了严重的术后伤口感染。
该病例表明，目前用于食品工业的 CNS 可能在人类感染中发挥作用。随着 MALDI-TOF 等技术的出现，原本被认为非致病性的病原体可能会被更频繁地识别。因此，必须更好地评估食品工业中使用的不同葡萄球菌菌株的风险。
