Gabrielsen C, Kols N I, Øye C, Bergh K, Afset J E
Department of Medical Microbiology, Clinic of Laboratory Medicine, Norway.
Department of Orthopedic Surgery, Clinic of Orthopedy, Rheumatology and Dermatology, St Olavs University Hospital, Norway.
New Microbes New Infect. 2017 Apr 8;18:8-14. doi: 10.1016/j.nmni.2017.03.006. eCollection 2017 Jul.
The coagulase-negative bacterium and closely related species are commonly isolated from or found in starter cultures of fermented sausage as well as fish and soy sauces, and have traditionally been considered nonpathogenic. Recently, however, a case of catheter-related bacteraemia caused by was reported. In the present study we identified and characterized a strain of isolated from a patient with a severe soft tissue infection, comparing it to and type strains in order to elucidate the virulence potential of the clinical strain. Genome comparison showed high degree of conservation between the clinical strain and the type strain used in food industry, as well as with The genome of the clinical strain contains few horizontally transferred regions and 37 putative virulence genes, including genes with similarity to leucocidin and genes involved in immune evasion, proinflammatory and cytolytic activity. However, it remains to be tested whether these putative virulence genes are expressed and functional. Although uncommon, may cause severe infection in previously healthy persons.
凝固酶阴性细菌及其密切相关菌种通常从发酵香肠、鱼类和酱油的发酵剂培养物中分离得到或发现，传统上被认为是非致病性的。然而，最近有报道称一例由该菌引起的导管相关菌血症。在本研究中，我们鉴定并表征了从一名患有严重软组织感染的患者身上分离出的该菌株，将其与该菌及其他类型菌株进行比较，以阐明临床菌株的毒力潜力。基因组比较显示，临床菌株与食品工业中使用的类型菌株以及其他菌株之间具有高度的保守性。临床菌株的基因组包含少量水平转移区域和37个推定的毒力基因，包括与杀白细胞素相似的基因以及参与免疫逃避、促炎和溶细胞活性的基因。然而，这些推定的毒力基因是否表达且具有功能仍有待测试。虽然不常见，但该菌可能在先前健康的个体中引起严重感染。
