Killackey Samuel A, Sorbara Matthew T, Girardin Stephen E
Department of Laboratory Medicine and Pathobiology, University of Toronto Toronto, ON, Canada.
Department of Immunology, University of Toronto Toronto, ON, Canada.
Front Cell Infect Microbiol. 2016 Mar 31;6:38. doi: 10.3389/fcimb.2016.00038. eCollection 2016.
Shigella is a Gram-negative bacterium that is responsible for shigellosis. Over the years, the study of Shigella has provided a greater understanding of how the host responds to bacterial infection, and how bacteria have evolved to effectively counter the host defenses. In this review, we provide an update on some of the most recent advances in our understanding of pivotal processes associated with Shigella infection, including the invasion into host cells, the metabolic changes that occur within the bacterium and the infected cell, cell-to-cell spread mechanisms, autophagy and membrane trafficking, inflammatory signaling and cell death. This recent progress sheds a new light into the mechanisms underlying Shigella pathogenesis, and also more generally provides deeper understanding of the complex interplay between host cells and bacterial pathogens in general.
志贺氏菌是一种革兰氏阴性细菌，可引起志贺氏菌病。多年来，对志贺氏菌的研究使人们对宿主如何应对细菌感染以及细菌如何进化以有效对抗宿主防御有了更深入的了解。在本综述中，我们介绍了对志贺氏菌感染相关关键过程理解的一些最新进展，包括侵入宿主细胞、细菌和被感染细胞内发生的代谢变化、细胞间传播机制、自噬和膜运输、炎症信号传导和细胞死亡。这些最新进展为志贺氏菌发病机制背后的机制提供了新的线索，也更广泛地使人们对宿主细胞与细菌病原体之间的复杂相互作用有了更深入的理解。
