Department of Psychology and Program in Neuroscience, Hamilton College, Clinton, NY 13323, United States.
Division of Behavioral Biology, Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21224, United States.
Neurobiol Learn Mem. 2019 May;161:115-121. doi: 10.1016/j.nlm.2019.04.003. Epub 2019 Apr 3.
The hippocampus, medial dorsal thalamus and the perirhinal and entorhinal cortices are essential for visual recognition memory whereas the neural substrates underlying olfactory recognition memories are less well characterized. In the present study we combined chemogenetic inactivation with a social odor recognition memory (SORM) task to test the hypothesis that the medial prefrontal cortex (mPFC) is involved in recognition memory. We demonstrate that temporary chemogenetic inactivation of the mPFC prior to an encoding session impairs social odor recognition memory, whereas silencing the mPFC just prior to the recognition session was without effect. Our data support the critical role of the mPFC in the formation rather than retrieval of social odor memory.
海马体、内侧背丘脑以及边缘下和内嗅皮层对于视觉识别记忆至关重要，而嗅觉识别记忆的神经基础则不太清楚。在本研究中，我们结合化学遗传失活和社交气味识别记忆（SORM）任务，以检验内侧前额叶皮层（mPFC）是否参与识别记忆的假说。我们证明，在编码阶段之前，mPFC 的暂时化学遗传失活会损害社交气味识别记忆，而在识别阶段之前抑制 mPFC 则没有影响。我们的数据支持 mPFC 在社交气味记忆的形成而非检索中起关键作用。
