敌敌畏对小鼠肝脏的影响。 需要说明的是，你原文中的“diflubenzuron”有误，正确的是“dichlorvos”，即敌敌畏。按照正确的词翻译为：敌敌畏对小鼠肝脏的影响。
Effects of diflubenzuron on the mouse liver.
作者信息
Young M F, Trombetta L D, Carson S
出版信息
J Appl Toxicol. 1986 Oct;6(5):343-8. doi: 10.1002/jat.2550060508.
Diflubenzuron (DFB), a potent inhibitor of insect chitin synthesis, was administered to Swiss Webster mice in a 30-day oral intubation study. Animal groups received either no treatment, vehicle control (Polyethylene glycol 400), or DFB suspensions at doses of 125, 500, and 2,000 mg/kg body weight. Hepatic glutathione S-transferase activity as well as morphological characteristics were studied. DFB was shown to elicit hepatocellular changes at all dose levels. The activities of three glutathione S-transferases (S-aryl, S-aralkyl, and S-epoxide) were all altered after DFB administration. Light microscopy revealed radial arrays of hepatocellular vacuolization between the portal and central vein areas. Electron-microscopic examination, verified by morphometric analysis, revealed degenerative changes as well as an increased volume density of the endoplasmic reticulum.
敌氟虫脲（DFB）是一种有效的昆虫几丁质合成抑制剂，在一项为期30天的经口插管研究中对瑞士韦伯斯特小鼠给药。动物组分别接受无处理、溶剂对照（聚乙二醇400）或剂量为125、500和2000mg/kg体重的DFB悬浮液。研究了肝脏谷胱甘肽S-转移酶活性以及形态学特征。结果表明，在所有剂量水平下，DFB均引发肝细胞变化。给药DFB后，三种谷胱甘肽S-转移酶（S-芳基、S-芳烷基和S-环氧化物）的活性均发生改变。光学显微镜检查显示，在门静脉和中央静脉区域之间存在呈放射状排列的肝细胞空泡化。经形态计量分析验证的电子显微镜检查显示存在退行性变化以及内质网体积密度增加。
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