Rejc Enrico, Angeli Claudia A
Kentucky Spinal Cord Injury Research Center, University of Louisville, 220 Abraham Flexner Way, Louisville, KY 40202, USA; Department of Neurological Surgery, University of Louisville, Louisville, KY, USA.
Kentucky Spinal Cord Injury Research Center, University of Louisville, 220 Abraham Flexner Way, Louisville, KY 40202, USA; Frazier Rehab Institute, KentuckyOne Health, 220 Abraham Flexner Way, Louisville, KY 40202, USA.
Phys Med Rehabil Clin N Am. 2019 May;30(2):337-354. doi: 10.1016/j.pmr.2018.12.009. Epub 2019 Mar 5.
Spinal cord epidural stimulation (scES) combined with activity-based training can promote lower limb motor function recovery in chronic, motor complete spinal cord-injured individuals. Task- and individual-specific scES parameters modulate the excitability of human spinal circuitry so that sensory information and residual descending input can serve as sources of control for generating motor patterns appropriate for standing, stepping, and volitionally moving the lower limb. Task-specific activity-based training with scES is crucial for promoting neural plasticity and motor function improvement. Future studies with more individuals and advanced stimulation technology are needed to better understand the recovery potential in this population.
脊髓硬膜外刺激（scES）联合基于活动的训练可促进慢性、运动完全性脊髓损伤个体的下肢运动功能恢复。任务和个体特异性的scES参数可调节人类脊髓回路的兴奋性，使感觉信息和残余下行输入能够作为控制源，以产生适合站立、行走和自主移动下肢的运动模式。基于任务的scES特异性活动训练对于促进神经可塑性和改善运动功能至关重要。未来需要开展涉及更多个体和采用先进刺激技术的研究，以更好地了解该人群的恢复潜力。
