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近期儿科哮喘诊断技术:学龄前哮喘的脉冲震荡技术和呼出气一氧化氮的应用。

Recent Diagnosis Techniques in Pediatric Asthma: Impulse Oscillometry in Preschool Asthma and Use of Exhaled Nitric Oxide.

机构信息

Division of Pulmonary Medicine, Cincinnati Children's Hospital Medical Center, Department of Pediatrics, University of Cincinnati College of Medicine, 3333 Burnet Avenue, MLC 7041, Cincinnati, OH 45229, USA.

出版信息

Immunol Allergy Clin North Am. 2019 May;39(2):205-219. doi: 10.1016/j.iac.2018.12.002.

Abstract

Objective measures of lung function are important in the diagnosis and management of asthma. Spirometry, the pulmonary function test most widely used in asthma, requires respiratory maneuvers that may be difficult for preschoolers. Impulse oscillometry (IOS) is a noninvasive method of measuring lung function during tidal breathing; hence, IOS is an ideal test for use in preschool asthma. Fractional exhaled nitric oxide (FeNO) levels correspond to eosinophilic inflammation and predict responsiveness to corticosteroids. Basic concepts of IOS, methodology, and interpretation, including available normative values, and recent findings regarding FeNO are reviewed in this article.

摘要

客观的肺功能指标在哮喘的诊断和治疗中非常重要。肺量计检查是哮喘中最广泛使用的肺功能测试,但需要进行可能对学龄前儿童有难度的呼吸动作。脉冲震荡(IOS)是一种在潮式呼吸期间测量肺功能的非侵入性方法;因此,IOS 是用于学龄前哮喘的理想测试。呼出气一氧化氮分数(FeNO)水平与嗜酸性粒细胞炎症相对应,并可预测对皮质类固醇的反应性。本文综述了 IOS 的基本概念、方法学和解释,包括可用的正常值以及关于 FeNO 的最新发现。

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