Nguyen Thinh H, Elios Megan, Fitzpatrick Anne M, Nyenhuis Sharmilee M, Phipatanakul Wanda
Division of Immunology, Boston Children's Hospital, Harvard Medical School, Boston, Mass.
Division of Allergy and Immunology, Department of Pediatrics, University of Chicago, Chicago, Ill.
J Allergy Clin Immunol Pract. 2025 Jul;13(7):1507-1515. doi: 10.1016/j.jaip.2025.05.004. Epub 2025 May 9.
Asthma is one of the most prevalent chronic disorders in children. Anti-inflammatory reliever (AIR) therapy and single maintenance and reliever therapy (SMART) have been adopted into the asthma management of adolescents and adults. However, limited evidence and guidance are currently available for asthma management of younger children with AIR therapy and SMART. Despite the potential benefits of these therapies, the evidence supporting their safety and efficacy in early childhood is evolving. Our review summarizes the current evidence regarding the risks and benefits of AIR therapy and SMART. Moreover, we also identified commonly known challenges of adopting AIR therapy and SMART for younger children as well as proposed potential solutions. Our review aims to offer a foundation for future research and clinical guidance to serve younger patients who could benefit from AIR therapy and SMART. This insight could ultimately lead to safer, more effective, and widely accessible asthma management options for children.
哮喘是儿童中最常见的慢性疾病之一。抗炎缓解剂(AIR)疗法和单药维持与缓解疗法(SMART)已被应用于青少年和成人的哮喘管理。然而,目前关于采用AIR疗法和SMART对年幼儿童进行哮喘管理的证据和指导有限。尽管这些疗法有潜在益处,但支持其在幼儿期安全性和有效性的证据仍在不断发展。我们的综述总结了关于AIR疗法和SMART风险与益处的现有证据。此外,我们还确定了在年幼儿童中采用AIR疗法和SMART常见的挑战,并提出了潜在的解决方案。我们的综述旨在为未来的研究和临床指导提供基础,以服务于可能从AIR疗法和SMART中受益的年幼儿童患者。这一见解最终可能为儿童带来更安全、更有效且更易获得的哮喘管理选择。