Graduate School of Tianjin Medical University, Tianjin, China.
Department of Respiratory, The Children's Hospital of Tianjin (Children's Hospital of Tianjin University), Tianjin, China.
Pediatr Pulmonol. 2021 Jul;56(7):1850-1856. doi: 10.1002/ppul.25374. Epub 2021 Mar 23.
Several studies have explored the predictive value of impulse oscillometry (IOS) for asthma exacerbations in childhood, but its specific parameters are still unclear. Therefore, we designed this meta-analysis to determine the related indicators of acute asthma attacks.
A comprehensive literature search was performed on July 9, 2020 based on PubMed, Embase, and Web of Science database. Weighted mean differences (WMDs) were calculated using fixed- or random-effects models.
A total of 615 patients from six trials were included in this analysis. IOS may be a useful tool to predict asthma exacerbations. And the results showed that R5 (WMD = -1.21, 95% CI: -1.55 to -0.87, p < .001), Fres (WMD = -1.34, 95% CI: -2.03 to -0.65, p = .018), and AX (WMD = -7.35, 95% CI: -9.94 to -4.76, p < .001) had significant correlation with asthma exacerbations. In addition, X5 may also predict the acute attack of asthma (WMD = 0.81, 95% CI: 0.56 to 1.01, p < .001).
R5, AX, Fres, and X5 may be able to identify the risk of an acute attack of asthma. Besides, our research further demonstrated that peripheral airway injury may play an important role in the acute attack of asthma.
已有多项研究探索了脉冲震荡（IOS）对儿童哮喘发作的预测价值，但具体参数仍不明确。因此，我们设计了这项荟萃分析，以确定与急性哮喘发作相关的指标。
我们于 2020 年 7 月 9 日对 PubMed、Embase 和 Web of Science 数据库进行了全面的文献检索。使用固定效应或随机效应模型计算加权均数差值（WMD）。
共有 615 名来自 6 项试验的患者纳入了本次分析。IOS 可能是一种预测哮喘发作的有用工具。结果显示，R5（WMD = -1.21，95%CI：-1.55 至 -0.87，p < 0.001）、Fres（WMD = -1.34，95%CI：-2.03 至 -0.65，p = 0.018）和 AX（WMD = -7.35，95%CI：-9.94 至 -4.76，p < 0.001）与哮喘发作有显著相关性。此外，X5 也可能预测哮喘的急性发作（WMD = 0.81，95%CI：0.56 至 1.01，p < 0.001）。
R5、AX、Fres 和 X5 可能能够识别哮喘急性发作的风险。此外，我们的研究进一步表明，周围气道损伤可能在哮喘急性发作中起重要作用。
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