Department of Materials, Department of Bioengineering and Institute of Biomedical Engineering, Imperial College London, London SW7 2BP, UK; PHI Biomed Co., 175 Yeoksam-ro, Gangnam-gu, Seoul 06247, South Korea.
Department of Chemical Engineering, Pohang University of Science and Technology (POSTECH), 77 Cheongam-ro, Nam-gu, Pohang, Gyeongbuk 37673, South Korea.
J Control Release. 2019 Jun 10;303:55-66. doi: 10.1016/j.jconrel.2019.04.003. Epub 2019 Apr 5.
Diagnostic and therapeutic nanoparticles have been actively investigated for the last few decades as new platforms for biomedical applications. Despite their great versatility and potency, nanoparticles have generally required further modification with biocompatible materials such as biopolymers and synthetic polymers for in vivo administration to improve their biological functions, stability, and biocompatibility. Among a variety of natural and synthetic biomaterials, hyaluronate (HA) has been considered a promising biomolecule with which to construct nanohybrid systems, as it can enable long-term and efficient delivery of nanoparticles to target sites as well as physiological stabilization of nanoparticles by forming hydrophilic shells. In this review, we first describe various kinds of HA derivatives and their interactions with nanoparticles, and discuss how to design and develop optimal HA-nanoparticle hybrid systems for biomedical applications. Furthermore, we show several exemplary applications of HA-nanoparticle hybrid systems and provide our perspectives to their futuristic translational applications.
在过去的几十年中，诊断和治疗纳米颗粒作为生物医学应用的新平台受到了广泛关注。尽管纳米颗粒具有很大的通用性和功效，但通常需要进一步用生物相容性材料（如生物聚合物和合成聚合物）进行修饰，以便进行体内给药，以改善其生物功能、稳定性和生物相容性。在各种天然和合成生物材料中，透明质酸（HA）已被认为是一种很有前途的生物分子，可用于构建纳米杂化系统，因为它可以使纳米颗粒能够长期有效地递送到靶位，并通过形成亲水性外壳来使纳米颗粒在生理上稳定。在这篇综述中，我们首先描述了各种 HA 衍生物及其与纳米颗粒的相互作用，并讨论了如何设计和开发用于生物医学应用的最佳 HA-纳米颗粒杂化系统。此外，我们展示了 HA-纳米颗粒杂化系统的几个示例应用，并对其未来的转化应用提供了我们的观点。
