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正常成年人的震颤:法罗群岛 1158 名成年人的一项基于人群的研究。

Tremor in normal adults: A population-based study of 1158 adults in the Faroe Islands.

机构信息

Department of Neurology, Yale School of Medicine, Yale University, New Haven, CT, USA; Department of Chronic Disease Epidemiology, Yale School of Public Health, Yale University, New Haven, CT, USA; Center for Neuroepidemiology and Clinical Neurological Research, Yale School of Medicine, Yale University, New Haven, CT, USA.

Department of Neurology, Yale School of Medicine, Yale University, New Haven, CT, USA.

出版信息

J Neurol Sci. 2019 May 15;400:169-174. doi: 10.1016/j.jns.2019.03.019. Epub 2019 Mar 21.

Abstract

There are virtually no population-based data on tremor in normal individuals. Using a population-based sample of 1158 normal adults ages 40-98 years in the Faroe Islands, we characterized the extent of normal action tremor across age and gender strata. Participants drew two Archimedes spirals with each hand, and tremor was systematically quantified by a senior movement disorder neurologist using a reliable and valid ordinal rating scale (ratings = 0-3). Tremor was nearly universal - 1145 (98.9%) participants had a total mean spiral score > 0. Older age was associated with more tremor (p < .001) and spiral scores were higher in males than females (p < .001). The proportion of individuals with a spiral rating ≥ 1.5 (i.e., more than mild tremor) was low (1.8% - 8.5%); however, this value reached 19.6% in left-hand spirals of males ≥70 years old. In this population-based study of more than one thousand normal adults, the vast bulk (i.e., 98.9%) had tremor on spiral drawing. In general, the tremor was mild. The proportion of individuals with tremor above the mild range varied across age and gender strata. These extensive data may be used as a gold standard for defining normal levels of tremor within adult populations.

摘要

关于正常个体的震颤,实际上没有基于人群的数据。我们使用法罗群岛的一个基于人群的 1158 名 40-98 岁正常成年人样本,描述了年龄和性别分层中正常动作震颤的程度。参与者用双手绘制两个阿基米德螺旋,由一位资深运动障碍神经病学家使用可靠和有效的等级评定量表(评分=0-3)系统地对震颤进行量化。震颤几乎普遍存在-1145(98.9%)名参与者的总平均螺旋评分>0。年龄越大,震颤越严重(p<0.001),男性的螺旋评分高于女性(p<0.001)。螺旋评分≥1.5(即震颤程度超过轻度)的个体比例较低(1.8%-8.5%);然而,在 70 岁以上的男性左手螺旋中,这一数值达到了 19.6%。在这项针对一千多名正常成年人的基于人群的研究中,绝大多数(即 98.9%)在绘制螺旋时存在震颤。总的来说,震颤是轻度的。震颤程度超过轻度范围的个体比例因年龄和性别分层而异。这些广泛的数据可用作定义成年人群体中震颤正常水平的金标准。

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