Massalou D, Masson C, Afquir S, Baqué P, Arnoux P-J, Bège T
Emergency Surgery Unit, University Hospital of Nice, CHU de Nice Hôpital Pasteur 2, Université de Nice Sophia-Antipolis, France; Biomechanical Applied Laboratory, UMRT24, IFSTTAR, Aix-Marseille University, France.
Biomechanical Applied Laboratory, UMRT24, IFSTTAR, Aix-Marseille University, France.
Clin Biomech (Bristol). 2019 May;65:34-40. doi: 10.1016/j.clinbiomech.2019.03.017. Epub 2019 Mar 28.
Data from biomechanical tissue sample studies of the human digestive tract are highly variable. The aim of this study was to investigate 4 factors which could modify the mechanical response of human colonic specimens placed under dynamic solicitation until tissue rupture: gender, age, shelf-life and conservation method.
We performed uniaxial dynamic tests of human colonic specimens. Specimens were taken according to three different protocols: refrigerated cadavers without embalming, embalmed cadavers and fresh colonic tissue. A total of 143 specimens were subjected to tensile tests, at a speed of 1 m s.
Young's modulus of the different conservation protocols are as follows: embalmed, 3.08 ± 1.99; fresh, 2.97 ± 2.59; and refrigerated 3.17 ± 2.05. The type of conservation does not modify the stiffness of the tissue (p = 0.26) but does modify the stress necessary for rupture (p < 0.001) and the strain required to obtain lesions of the outer layer and the inner layer (p < 0.001 and p < 0.05, respectively). Gender is also a factor responsible for a change in the mechanical response of the colon. The age of the subjects and the shelf-life of the bodies did not represent factors influencing the mechanical behavior of the colon (p > 0.05).
The mechanical response of the colon tissue showed a biphasic injury process depending on gender and method of preservation. The age and shelf-life of anatomical subjects do not alter the mechanical response of the colon.
来自人体消化道生物力学组织样本研究的数据差异很大。本研究的目的是调查4个因素，这些因素可能会改变在动态拉伸直至组织破裂情况下人体结肠标本的力学反应：性别、年龄、保存期限和保存方法。
我们对人体结肠标本进行了单轴动态测试。标本根据三种不同方案采集：未防腐冷藏尸体、防腐尸体和新鲜结肠组织。总共143个标本以1米/秒的速度进行拉伸试验。
不同保存方案的杨氏模量如下：防腐的为3.08±1.99；新鲜的为2.97±2.59；冷藏的为3.17±2.05。保存类型不会改变组织的刚度（p = 0.26），但会改变破裂所需的应力（p < 0.001）以及外层和内层出现损伤所需的应变（分别为p < 0.001和p < 0.05）。性别也是导致结肠力学反应变化的一个因素。受试者的年龄和尸体的保存期限并非影响结肠力学行为的因素（p > 0.05）。
结肠组织的力学反应显示出一个双相损伤过程，这取决于性别和保存方法。解剖对象的年龄和保存期限不会改变结肠的力学反应。
