College of Pharmacy, Yonsei Institute of Pharmaceutical Sciences, Yonsei University, 85 Songdogwahak-ro, Incheon, South Korea; Department of Health Administration, Dongseo University, Busan, South Korea.
Department of Psychiatry, CHA University College of Medicine, Bundang CHA Hospital, Gyeonggi-do, South Korea.
J Affect Disord. 2019 May 15;251:287-292. doi: 10.1016/j.jad.2019.03.079. Epub 2019 Mar 26.
Patients with psychiatric disorders are considered to be at increased suicide risk following discharge. We aimed to identify suicide risk during one year after discharge among adults with psychiatric disorders compared to those without psychiatric disorders.
This study used a nationally representative cohort including patients discharged with an initial primary diagnosis of a psychiatric disorder and control subjects selected by 1:3 case-control propensity matching between 2005 and 2012. The dependent variable was death by suicide during one year after discharge. Adjusted hazard ratios (AHR) of suicide risk were estimated by the Cox proportional hazard model.
In a cohort of 50,868 adults, the suicide rate was higher for patients with a psychiatric disorder compared to non-psychiatric patients (AHR 7.2, 95% confidence interval [CI] 4.9-10.6), especially in young adults (AHR 18.6, 95%CI 6.4-54.1), and patients with multiple psychiatric disorders (AHR 12.5, 95%CI 7.9-20.0). Among psychiatric disorder categories, the suicide rate was highest for depressive disorder, followed by bipolar disorder, substance use disorder, schizophrenia. Patients with psychiatric disorders who received outpatient care during one year after discharge were at lower risk of suicide than those who did not receive or otherwise received fewer outpatient treatments.
Data were not available on risk factors such as suicide attempts. The suicide risk for shorter periods could not be determined due to the limited data.
Patients with psychiatric disorders are at high suicide risk during one year after hospital discharge. Outpatient follow-up is an effective prevention strategy.
精神障碍患者在出院后被认为自杀风险增加。我们旨在确定与无精神障碍患者相比,精神障碍患者在出院后一年内的自杀风险。
本研究使用了一个全国代表性的队列,包括在 2005 年至 2012 年期间首次以精神障碍为主要诊断出院的患者和通过 1:3 病例对照倾向匹配选择的对照组。因变量是出院后一年内自杀死亡。通过 Cox 比例风险模型估计自杀风险的调整危险比(AHR)。
在一个由 50868 名成年人组成的队列中,与非精神障碍患者相比,精神障碍患者的自杀率更高(AHR 7.2,95%置信区间[CI]4.9-10.6),尤其是在年轻成年人(AHR 18.6,95%CI 6.4-54.1)和患有多种精神障碍的患者(AHR 12.5,95%CI 7.9-20.0)。在精神障碍类别中,自杀率最高的是抑郁症,其次是双相情感障碍、物质使用障碍、精神分裂症。在出院后一年内接受门诊治疗的精神障碍患者的自杀风险低于未接受或接受较少门诊治疗的患者。
缺乏自杀企图等风险因素的数据。由于数据有限,无法确定较短时间内的自杀风险。
精神障碍患者在出院后一年内自杀风险很高。门诊随访是一种有效的预防策略。