Kauppinen R A, Nicholls D G
J Neurochem. 1986 Dec;47(6):1864-9. doi: 10.1111/j.1471-4159.1986.tb13100.x.
Synaptosomal glycolysis is stimulated eight- to 10-fold when the respiratory chain is inhibited by cyanide or by anoxia. However, the stimulation is transient and after 15 min declines toward the preanoxic rate. The decline is not seen when Ca2+ is absent or when the respiratory chain is inhibited by rotenone. The decline in glycolysis is reversible, is not due to substrate exhaustion, and is the cause, rather than the effect, of lowered synaptosomal ATP/ADP ratios. The failure to maintain glycolysis when the terminal oxidase of the respiratory chain is inhibited may have relevance to the sensitivity of the brain to anoxic damage.
当呼吸链被氰化物或缺氧抑制时，突触体糖酵解被刺激8到10倍。然而，这种刺激是短暂的，15分钟后朝着缺氧前的速率下降。当不存在Ca2+或呼吸链被鱼藤酮抑制时，这种下降就不会出现。糖酵解的下降是可逆的，不是由于底物耗尽，并且是突触体ATP/ADP比率降低的原因而非结果。当呼吸链的末端氧化酶被抑制时无法维持糖酵解，这可能与大脑对缺氧损伤的敏感性有关。
