Department of Pediatrics, AIIMS, New Delhi, India. Correspondence to: Dr Rachna Seth, Professor, Department of Pediatrics, All India Institute of Medical Sciences, New Delhi, India.
Department of Microbiology, AIIMS, New Delhi, India.
Indian Pediatr. 2019 Mar 15;56(3):229-236.
Invasive fungal infections are important causes of morbidity and mortality particularly in high-risk patients. Recognizing such infections is often difficult because of non-specific symptoms and clinical signs. Timely diagnosis is also a challenge due to difficulty in obtaining adequate volume of samples, need for anaesthesia to perform certain diagnostic procedures, and insufficient data and experience related to fungal biomarkers and molecular detection tests. This results in widespread use of empiric broad spectrum antifungal agents with the consequent emergence of drug-resistant strains. This review focusses on the definition, clinical and microbial profile and diagnostic modalities for invasive fungal infections.
侵袭性真菌感染是发病率和死亡率的重要原因，特别是在高危患者中。由于非特异性症状和临床体征，此类感染通常难以识别。由于难以获得足够量的样本、需要麻醉来进行某些诊断程序以及与真菌生物标志物和分子检测相关的数据和经验不足，及时诊断也是一个挑战。这导致广泛使用经验性广谱抗真菌药物，随之出现耐药菌株。本文重点介绍了侵袭性真菌感染的定义、临床和微生物特征以及诊断方法。
