ENT Service, Hospital Universitario de Canarias, Ctra. Ofra S/N La Cuesta, 38320, La Laguna, Santa Cruz de Tenerife, Spain.
Intraoperative Neuromonitoring Unit, Hospital Universitario de Canarias, Ctra. Ofra S/N La Cuesta, 38320, La Laguna, Santa Cruz de Tenerife, Spain.
Eur Arch Otorhinolaryngol. 2019 Jul;276(7):1915-1920. doi: 10.1007/s00405-019-05416-6. Epub 2019 Apr 6.
To assess the diagnostic capacity of intraoperative neurophysiological monitoring with respect to "gold standard" microscopic findings of facial canal dehiscence in middle ear cholesteatoma surgery.
STUDY DESIGN, PATIENTS AND SETTING: We carried out a retrospective cohort study of 57 surgical interventions for cholesteatoma between 2008 and 2013 at Hospital Universitario de Canarias, Spain.
Each patient underwent preoperative computed tomography (CT), intraoperative neurophysiological monitoring and intraoperative inspection of the facial nerve during microsurgery. Diagnostic concordance on the presence/absence of facial canal dehiscence was assessed in 54 surgical interventions.
Presence of facial canal dehiscence.
Of 57 interventions, 39 were primary surgeries; 11 (28.2%) showed facial canal dehiscence. and 18 were revision surgeries; 6 (33.3%) showed facial canal dehiscence. The facial nerve was not damaged in any patient. Facial canal dehiscence was observed in 17 (29.82%) interventions. We used intraoperative microscopic findings as the gold standard. Neurophysiological study showed a sensitivity of 94.1, specificity 97.3, positive predictive value (PPV) 57.8 and negative predictive value of 97.2. CT showed a sensitivity of 64.7, specificity 78.4, PPV 57.8 and negative predictive value of 82.
Our neurophysiological study showed greater sensitivity and higher PPV than CT for the detection of facial canal dehiscence. We found no relationship between disease progression time and the presence of facial canal dehiscence.
评估术中神经生理学监测对面神经管在中耳胆脂瘤手术中裂开的“金标准”显微镜发现的诊断能力。
研究设计、患者和设置:我们对 2008 年至 2013 年在西班牙拉古纳大学医院进行的 57 例胆脂瘤手术进行了回顾性队列研究。
每位患者均接受术前计算机断层扫描(CT)、术中神经生理学监测和显微镜手术期间面神经的术中检查。在 54 例手术干预中评估了面神经管有无裂开的存在/缺失的诊断一致性。
面神经管有无裂开。
在 57 例干预中,39 例为原发性手术;11 例(28.2%)显示面神经管裂开。18 例为翻修手术;6 例(33.3%)显示面神经管裂开。面神经在任何患者中均未受损。面神经管在 17 例(29.82%)手术中观察到。我们使用术中显微镜发现作为金标准。神经生理学研究显示出 94.1%的敏感性、97.3%的特异性、57.8%的阳性预测值(PPV)和 97.2%的阴性预测值。CT 显示出 64.7%的敏感性、78.4%的特异性、57.8%的 PPV 和 82.0%的阴性预测值。
我们的神经生理学研究显示,与 CT 相比,检测面神经管裂开的敏感性更高,PPV 更高。我们未发现疾病进展时间与面神经管裂开存在之间的关系。