Boan Peter, Gardam Dianne
a Department of Microbiology, PathWest Laboratory Medicine WA , Fiona Stanley Hospital , Murdoch , Australia.
b Department of Infectious Diseases , Fiona Stanley Hospital , Murdoch , Australia.
J Chemother. 2019 May;31(3):137-140. doi: 10.1080/1120009X.2019.1595895. Epub 2019 Apr 7.
Candidemia is a common invasive fungal infection with a high mortality rate. We performed a retrospective audit of candidemia at a tertiary centre in Western Australia, 2005-2014. There were 167 episodes of candidemia due to 173 isolates of Candida. Candida albicans (40.5%), Candida glabrata complex (30.6%), Candida parapsilosis complex (14.4%) were the most common species causing candidemia across the study. Of the tested isolates, 17.7% (11/62) were non-susceptible to fluconazole and 13.6% (9/66) non-susceptible to caspofungin. 22.8% (8/35) C. glabrata complex were fluconazole resistant and 17.1% (6/35) were non-susceptible to caspofungin. Candida glabrata complex was more common in the latter time period, but there were no susceptibility changes over time. In our setting, the prevalence of C. glabrata complex and antifungal non-susceptibility is high, and the prevalence of C. glabrata complex is increasing.
念珠菌血症是一种常见的侵袭性真菌感染，死亡率很高。我们对2005年至2014年西澳大利亚一家三级医疗中心的念珠菌血症进行了回顾性审计。共有173株念珠菌引起了167例念珠菌血症。在整个研究中，白色念珠菌（40.5%）、光滑念珠菌复合体（30.6%）、近平滑念珠菌复合体（14.4%）是引起念珠菌血症最常见的菌种。在检测的分离株中，17.7%（11/62）对氟康唑不敏感，13.6%（9/66）对卡泊芬净不敏感。22.8%（8/35）的光滑念珠菌复合体对氟康唑耐药，17.1%（6/35）对卡泊芬净不敏感。光滑念珠菌复合体在后一时间段更为常见，但随着时间推移药敏性没有变化。在我们的研究环境中，光滑念珠菌复合体的患病率和抗真菌药物不敏感性较高，且光滑念珠菌复合体的患病率正在上升。
