收缩的骨骼肌释放的氯化钾可能会刺激其肥大的发展。

Kravchenko Irina V, Furalyov Vladimir A, Popov Vladimir O

Bach Institute of Biochemistry, Research Center of Biotechnology of the Russian Academy of Sciences, Leninsky Ave. 33, Bld. 2, Moscow, 119071, Russia.

Biochem Biophys Rep. 2019 Mar 21;18:100627. doi: 10.1016/j.bbrep.2019.100627. eCollection 2019 Jul.

The effects of potassium chloride on the expression of IGF-1 splice forms and myoblast proliferation were investigated. KCl at the concentrations of 7-12 mM stimulated the synthesis of IGF-1 and mechano growth factor (MGF) in murine myoblasts as well as in myotubes both at the mRNA and protein levels. Pan-calcium channel blocker CdCl completely abolished stimulation of growth factor expression, whereas blocker of HCN and Na1.4 channels ZD7288 drastically reduced it. In addition, potassium chloride stimulated myoblast proliferation, while IGF-1 autocrine signaling inhibition partially suppressed these mitogenic effects.

研究了氯化钾对IGF-1剪接形式表达和成肌细胞增殖的影响。浓度为7-12 mM的氯化钾在mRNA和蛋白质水平上均刺激了小鼠成肌细胞以及肌管中IGF-1和机械生长因子（MGF）的合成。泛钙通道阻滞剂CdCl完全消除了对生长因子表达的刺激，而HCN和Na1.4通道阻滞剂ZD7288则使其大幅降低。此外，氯化钾刺激成肌细胞增殖，而IGF-1自分泌信号抑制则部分抑制了这些促有丝分裂作用。