Department of Oncology, Oslo University Hospital Oslo Norway.
Department of Transplantation Medicine, Oslo University Hospital Oslo Norway.
BJS Open. 2018 Oct 25;3(2):180-185. doi: 10.1002/bjs5.50116. eCollection 2019 Apr.
Liver transplantation for patients with non-resectable colorectal liver metastases offers increased survival, with median overall survival of more than 5 years. The aim of this study was to compare quality of life before and up to 3 years after liver transplantation for colorectal liver metastases.
Quality of life was assessed using the European Organisation for Research and Treatment of Cancer QLQ-C30 questionnaire version 3.0. The patients received the questionnaire before and up to 3 years after liver transplantation.
Some 23 patients were included in the analysis. Three months after liver transplantation they reported reduced quality of life (global health status scale), physical function and role function, and increased dyspnoea. At 6 months, global health status, physical function and role function had returned to pretransplant values. Three years after liver transplantation all symptom and function scores were comparable to baseline values. Patients with high scores for fatigue, pain and appetite loss at baseline had reduced 3-year overall survival.
Patients with non-resectable colorectal liver-only metastases receiving liver transplantation had good long-term quality of life. Patients with high symptom scores before transplantation had reduced 3-year overall survival.
对于无法切除的结直肠癌肝转移患者，肝移植可提高生存率，中位总生存期超过 5 年。本研究旨在比较结直肠癌肝转移肝移植前后 3 年内的生活质量。
使用欧洲癌症研究与治疗组织的 EORTC QLQ-C30 问卷 3.0 版评估生活质量。患者在肝移植前和移植后 3 年内接受问卷调查。
共有 23 名患者纳入分析。肝移植后 3 个月，患者报告生活质量（整体健康状况量表）、身体功能和角色功能下降，呼吸困难增加。6 个月时，整体健康状况、身体功能和角色功能已恢复到移植前的水平。肝移植 3 年后，所有症状和功能评分均与基线值相当。基线时疲劳、疼痛和食欲丧失评分较高的患者，3 年总生存率降低。
接受肝移植的不可切除的结直肠癌肝转移患者具有良好的长期生活质量。移植前症状评分较高的患者 3 年总生存率降低。
