Andersen Marit Helen, Dueland Svein, Hagness Morten, Vidnes Tone, Finstad Ellen Drolsum, Wahl Astrid Klopstad, Foss Aksel
Division of Cancer Medicine, Surgery and Transplant, Oslo University Hospital Rikshospitalet, Oslo, Norway.
Scand J Caring Sci. 2012 Dec;26(4):713-9. doi: 10.1111/j.1471-6712.2012.00984.x. Epub 2012 Mar 27.
To study quality of life (QoL) in patients with liver metastases from colorectal carcinoma (CRC) following liver transplantation (Ltx).
Ten patients participated in a prospective explorative pilot study. Inclusion criteria were nonresectable liver-only metastases determined by CT/MRI-, PET/CT- scans and colonoscopy, and ECOG 0-1. Primary outcome was QoL assessed by the EORTC-C30 questionnaires at baseline, and at 3, 6 and 12 months after Ltx.
The patients' age ranged from 50 to 63 years. Nine of 10 patients were observed for 12 months. One patient did not return the form at 6 months and died shortly after because of recurrence of the malignant disease. Compared to baseline, Ltx resulted in sustained excellent global health status scale (score of 100) in one patient, improved scores in 4 and unchanged scores in 3 patients at 12 months. The majority of the patients also reported good functional scores at follow-ups. Although two patients had marked symptoms both before and after Ltx, the patients in general reported low levels of pain and fatigue before and after surgery.
The present study indicates that CRC patients with liver-only metastases who receive Ltx have good QoL and have mostly minor symptoms the first year after Ltx.
研究肝移植（Ltx）后结直肠癌（CRC）肝转移患者的生活质量（QoL）。
10名患者参与了一项前瞻性探索性试点研究。纳入标准为经CT/MRI、PET/CT扫描及结肠镜检查确定为不可切除的仅肝转移灶，且ECOG评分为0 - 1。主要结局是通过EORTC - C30问卷在基线时以及Ltx后3、6和12个月评估QoL。
患者年龄在50至63岁之间。10名患者中有9名被观察了12个月。1名患者在6个月时未返还表格，且因恶性疾病复发不久后死亡。与基线相比，12个月时，1名患者Ltx后维持了极佳的总体健康状况量表评分（100分），4名患者评分改善，3名患者评分未变。大多数患者在随访时功能评分也良好。尽管两名患者在Ltx前后均有明显症状，但总体而言患者在手术前后疼痛和疲劳水平较低。
本研究表明，接受Ltx的仅肝转移CRC患者生活质量良好，且在Ltx后第一年大多症状较轻。
