Mihaileanu Razvan, Neamtiu Iulia Adina, Bloom Michael, Stamatian Florin
1 Gynecology Department, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania.
IMOGEN Research Institute, Cluj-Napoca, Romania.
Med Pharm Rep. 2019 Jan;92(1):59-65. doi: 10.15386/cjmed-984. Epub 2019 Jan 15.
In the development of any human body, defects may occur, resulting in the occurrence of congenital malformations, also referred to as birth defects. The aim of this preliminary study was to assess the prevalence of birth defects registered during a period of 5 years in Tarnaveni area. As Tarnaveni is located in close proximity to a former chemical plant, a recognized hazardous waste site, we conducted this pilot study to assess the prevalence of birth defects, in order to evaluate the need for a more comprehensive investigation of a potential relation between the exposure to toxic metals contaminating the environmental media as a result of the past industrial activities, and the prevalence of the birth defects in this area.
We abstracted birth information (gestational age at delivery (GA), birth weight (BW), birth length (BL), head circumference (HC), and major structural birth defects), from medical records at "Dr. Gheorghe Marinescu" Tarnaveni Municipal Hospital, of the 2010-2014 period. We expressed BW as Z-scores relative to expected mean values at each gestational age for a reference population, calculated the ponderal index, and determined the 5 years birth defects prevalence among live births during the study interval.
The 5 years (2010-2014) prevalence of birth defects, was 3.3% (95% confidence interval (CI): 2.47, 4.09). There were n = 163 (8.7%) preterm deliveries (less than 37 weeks of gestation at delivery), mean birth weight was 3108.3 g (standard deviation (SD) = 517.1), ranging from 450-4600 g, and n = 187 (10%) were low birth weight (LBW) (less than 2500 g). The ponderal index was 2.2 g/cm on average (SD = 0.5), with range 1.2-20.7 g/cm.
While preliminary, our data show a 5 years (2010-2014) prevalence of major structural birth defects among newborns from Tarnaveni area of 3.3%. These pilot results indicate the need for a more comprehensive investigation of a potential relation between the exposure to toxic metals contaminating the environmental media as a result of the past industrial activities and the prevalence of the birth defects in Tarnaveni area.
在人体发育过程中，可能会出现缺陷，导致先天性畸形的发生，也称为出生缺陷。本初步研究的目的是评估塔尔纳韦尼地区5年内登记的出生缺陷患病率。由于塔尔纳韦尼靠近一个曾经的化工厂，一个公认的危险废物场地，我们开展了这项试点研究，以评估出生缺陷的患病率，从而评估是否有必要对过去工业活动导致环境介质受有毒金属污染与该地区出生缺陷患病率之间的潜在关系进行更全面的调查。
我们从“格奥尔基·马林内斯库医生”塔尔纳韦尼市立医院2010 - 2014年期间的医疗记录中提取了出生信息（分娩时的孕周（GA）、出生体重（BW）、出生身长（BL）、头围（HC）以及主要结构性出生缺陷）。我们将BW表示为相对于参考人群每个孕周预期均值的Z分数，计算了体重指数，并确定了研究期间活产儿中5年出生缺陷患病率。
2010 - 2014年5年间出生缺陷患病率为3.3%（95%置信区间（CI）：2.47，4.09）。有n = 163例（8.7%）早产（分娩时孕周小于37周），平均出生体重为3108.3克（标准差（SD）= 517.1），范围为450 - 4600克，n = 187例（10%）为低出生体重（LBW）（小于2500克）。体重指数平均为2.2克/厘米（SD = 0.5），范围为1.2 - 20.7克/厘米。
虽然是初步数据，但我们的数据显示，2010 - 2014年期间塔尔纳韦尼地区新生儿中主要结构性出生缺陷的患病率为3.3%。这些试点结果表明有必要对过去工业活动导致环境介质受有毒金属污染与塔尔纳韦尼地区出生缺陷患病率之间的潜在关系进行更全面的调查。
