Torres Amalia García, González-Andrade Alejandro, Fernández Muñoz Juan José, García Miguel Pérez, Vergara-Moragues Esperanza
Hogar GERASA, Unidad Gestión Clínica de Enfermedades Infecciosas, Hospital Universitario de Puerto Real , Cádiz , Spain.
Mind, Brain and Behavior Research Center (CIMCYC), University of Granada , Granada , Spain.
AIDS Care. 2019 Dec;31(12):1540-1547. doi: 10.1080/09540121.2019.1601673. Epub 2019 Apr 7.
Objective memory is one of the most affected cognitive areas in patients with HIV and perhaps one of the best predictors of daily functioning problems. Its relationship with biological markers, mood symptoms, and cognitive complaint is unclear and has received little attention in native Spanish-speakers. The goal of this study is to explore the relationships between the above-mentioned variables and their prediction of objective memory performance in native Spanish-speakers. HIV-related biological markers, mood symptoms, cognitive complaint, and objective memory were assessed in a sample native Spanish-speaking HIV patient with possible cognitive impairment. The results revealed deficit in short- and long-term memory while recognition was retained. Hierarchical regression analysis showed that the combination of independent variables significantly predicted performance in recognition, indicating that the pattern of impairment in short- and long-term memory is related to a difficulty to learn new information discriminately. The non-prediction of short- and long-term memory performance may be related to the inability to estimate the deficit in objective memory. These results show the need to perform specific interventions in mnesic processes, in view of the relation between this cognitive process and patients' daily functioning.
客观记忆是艾滋病毒患者中受影响最严重的认知领域之一，可能也是日常功能问题的最佳预测指标之一。其与生物学标志物、情绪症状和认知主诉之间的关系尚不清楚，并且在以西班牙语为母语的人群中很少受到关注。本研究的目的是探讨上述变量之间的关系及其对以西班牙语为母语者客观记忆表现的预测作用。在一组可能存在认知障碍的以西班牙语为母语的艾滋病毒患者样本中，评估了与艾滋病毒相关的生物学标志物、情绪症状、认知主诉和客观记忆。结果显示，短期和长期记忆存在缺陷，而识别能力得以保留。分层回归分析表明，自变量的组合显著预测了识别表现，这表明短期和长期记忆的损伤模式与难以有区别地学习新信息有关。短期和长期记忆表现无法被预测，可能与无法估计客观记忆中的缺陷有关。鉴于这种认知过程与患者日常功能之间的关系，这些结果表明有必要对记忆过程进行特定干预。
