ANTIOXIDANT PROTECTION STATUS AND LIPOPEROXIDATION PROCESSES IN WOMEN WITH PREMATURE BIRTH IN DIFFERENT TERMS OF GESTATION.

The purpose of the study is examination the dynamics of antioxidant defense indicators and lipoperoxidation processes in women with pregnancy termination different periods. 227 pregnant women were examined, 190 of them had clinical signs of premature birth in the gestation period of 23-36 weeks. Formation of clinical groups was carried out depending on the term of pregnancy in the form of premature and timely birth. 48 women with early pregnancy termination were included in group I, which ended in childbirth in the period from 23 to 27 weeks. All pregnant women with risk of early pregnancy termination had the following distribution depending on the gestational period: 23-25 weeks - 23 pregnant women (Ia subgroup); 26-27 weeks - 25 pregnant women (Ib subgroup). 142 women were included in group II with late term pregnancy termination in the period from 28 to 36 weeks, which depending on the term of premature birth were divided into subgroups: IIa - 38 people, 28-30 weeks; IIb - 48 people, 31-33 weeks; IIс - 56 people, 34-36 weeks. The III (control) group included 37 women with a physiological course of pregnancy, which ended in childbirth without complications at the time of 38-41 weeks. The criteria for including women into groups were: young reproductive age, single-pregnancy, absence of gestosis, acute and chronic gynecological and somatic diseases. Diagnosis of preterm labor was carried out in the presence of abdominal pain syndrome and structural changes in the cervix. The research was carried out in compliance with the bioethics principles. In women with pregnancy termination in the period of 23-36 weeks in relation to women with the physiological course of pregnancy, which ended with childbirth without complications in the period of 38-41 weeks, there is an imbalance in the work of first and second lines antioxidants of antioxidant defense, which provokes the generation of oxygen excessive amounts active forms, initiating processes of lipoperoxidation with the essential malonic dialdehyde formation. In women with termination of pregnancy in the early stages of 23-27 weeks in relation to women with the physiological course of pregnancy there is a tension in antioxidant defense with a significant increase in lipoperoxidation, which is confirmed by a decrease in the activity of superoxide dismutase (34%), an increase in the level of ceruloplasmin (87%), diene (30%), malonic dialdehyde (by 178%), Schiff bases (by 28%) with an ambiguous change in the activity of catalase - an increase of 28% in the period of 23-25 weeks, a decrease by 16% in the period of 26-27 weeks. In women with termination of pregnancy in late periods of 28-36 weeks in relation to women with the physiological course of pregnancy, the inclusion of compensatory reactions of antioxidant defense against the background of lipoproxidation increase is observed, which is confirmed by an increase in the activity of SOD (17%), glutathione peroxidase (24% ), CP (117%), diethine (by 55%), MDA (by 106%), and SBs (by 18%) with a decrease in catalase activity (by 45%). The antioxidant protection imbalance of the body and the intensification of lipoperoxidation processes is one of the components of pregnancy termination pathogenesis and may contribute in combination with other complications.