Department of Tropical Diseases- São Paulo State University-UNESP/Botucatu-Brazil, Botucatu, São Paulo, Brazil.
Department of Microbiology and Immunology- São Paulo State University-UNESP/Botucatu-Brazil, Botucatu, São Paulo, Brazil.
PLoS One. 2021 May 21;16(5):e0251619. doi: 10.1371/journal.pone.0251619. eCollection 2021.
Redox imbalance may compromise the homeostasis of physiological processes indispensable to gestational development in HIV-infected women. The present study aims to evaluate markers of the redox system in the development of pregnancy of these women. HIV-positive pregnant women, HIV-negative pregnant women and non-pregnant were studied. Redox markers superoxide dismutase (SOD), catalase (CAT), protein carbonylation and malondialdehyde (MDA) were assessed at first or second trimester, third trimester and postpartum from pregnant and from non-pregnant women. According to the longitudinal analysis model, CAT activity was increased in the postpartum in HIV-positive women and before delivery in HIV-negative women. Increased carbonylation was observed in the pre-delivery period of HIV-negative pregnant women and MDA concentrations were higher in HIV-positive pregnant women compared to those non-infected by HIV at all times. According to the factorial model, higher SOD and CAT activities were observed in HIV-positive women in the initial months of pregnancy and in non-pregnant women. Carbonylation at third trimester was more evident in HIV-negative pregnant women. MDA levels were higher in HIV-positive pregnant women. Increased oxidative stress may occur in HIV-infected pregnant women. Nevertheless, the HIV virus is not solely responsible for this process; instead, mechanisms inherent to the pregnancy seem to play a role in this imbalance.
氧化还原失衡可能会损害 HIV 感染妇女妊娠发育所必需的生理过程的动态平衡。本研究旨在评估这些妇女妊娠发育过程中氧化还原系统的标志物。研究了 HIV 阳性孕妇、HIV 阴性孕妇和非孕妇。在妊娠和非妊娠妇女的第一或第二孕期、第三孕期和产后评估氧化还原标志物超氧化物歧化酶 (SOD)、过氧化氢酶 (CAT)、蛋白羰基化和丙二醛 (MDA)。根据纵向分析模型，HIV 阳性妇女产后 CAT 活性增加，HIV 阴性妇女分娩前 CAT 活性增加。在 HIV 阴性孕妇的分娩前期间观察到碳酰化增加，与未感染 HIV 的孕妇相比，所有时间点 HIV 阳性孕妇的 MDA 浓度均较高。根据析因模型，HIV 阳性孕妇在妊娠初期和非孕妇中观察到更高的 SOD 和 CAT 活性。在 HIV 阴性孕妇中，第三孕期的碳酰化更为明显。MDA 水平在 HIV 阳性孕妇中较高。HIV 感染孕妇可能会发生氧化应激增加。然而，HIV 病毒并不是导致这种情况的唯一原因；相反，妊娠固有的机制似乎在这种失衡中发挥了作用。
