人α干扰素对表皮生长因子受体的调节作用
Modulation of epidermal growth factor receptors by human alpha interferon.
作者信息
Zoon K C, Karasaki Y, zur Nedden D L, Hu R Q, Arnheiter H
出版信息
Proc Natl Acad Sci U S A. 1986 Nov;83(21):8226-30. doi: 10.1073/pnas.83.21.8226.
Abstract
Treatment of Madin-Darby bovine kidney (MDBK) cells with human interferon (IFN)-alpha 2 at 37 degrees C results in a dose-dependent inhibition of cell growth and a reduction of the subsequent binding of 125I-labeled epidermal growth factor (EGF) at 4 degrees C. Human IFN-beta and -gamma, which exhibit little antiviral and antiproliferative activities on MDBK cells, have little effect on cell growth or the binding of 125I-labeled EGF to these cells. The binding of EGF is decreased after exposure to IFN-alpha for greater than 8 hr. Scatchard analyses of the EGF binding data indicate that a 20-hr exposure period results in a decrease in the apparent number of cell-surface EGF receptors and a reduction in the affinity of EGF for its receptor. The rate of internalization of EGF by MDBK cells does not appear to be affected by IFN treatment.
摘要
在37摄氏度下用人干扰素（IFN）-α2处理马-达二氏牛肾（MDBK）细胞，会导致细胞生长受到剂量依赖性抑制，且在4摄氏度下125I标记的表皮生长因子（EGF）的后续结合减少。人IFN-β和-γ对MDBK细胞几乎没有抗病毒和抗增殖活性，对细胞生长或125I标记的EGF与这些细胞的结合几乎没有影响。暴露于IFN-α超过8小时后，EGF的结合减少。对EGF结合数据的Scatchard分析表明，20小时的暴露期会导致细胞表面EGF受体的表观数量减少，以及EGF对其受体的亲和力降低。MDBK细胞内化EGF的速率似乎不受IFN处理的影响。
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本文引用的文献
1
Growth factors: mechanism of action and relation to oncogenes.生长因子：作用机制及其与癌基因的关系。
Cell. 1984 May;37(1):9-20. doi: 10.1016/0092-8674(84)90296-4.
2
Interferon receptor interaction. Internalization of interferon alpha 2 and modulation of its receptor on human cells.干扰素受体相互作用。人细胞中干扰素α2的内化及其受体的调节。
Eur J Biochem. 1984 May 2;140(3):461-7. doi: 10.1111/j.1432-1033.1984.tb08125.x.
3
Close similarity of epidermal growth factor receptor and v-erb-B oncogene protein sequences.表皮生长因子受体与v-erb-B癌基因蛋白序列的高度相似性。
Nature. 1984;307(5951):521-7. doi: 10.1038/307521a0.
4
Transforming growth factor-beta controls receptor levels for epidermal growth factor in NRK fibroblasts.转化生长因子-β调控NRK成纤维细胞中表皮生长因子的受体水平。
Cell. 1984 Jan;36(1):35-41. doi: 10.1016/0092-8674(84)90071-0.
5
Human interferon alpha enters cells by receptor-mediated endocytosis.人干扰素α通过受体介导的内吞作用进入细胞。
Virology. 1983 Oct 15;130(1):195-203. doi: 10.1016/0042-6822(83)90127-7.
6
Platelet-derived growth factor treatment decreases the affinity of the epidermal growth factor receptors of Swiss 3T3 cells.血小板衍生生长因子处理可降低瑞士3T3细胞表皮生长因子受体的亲和力。
J Biol Chem. 1983 Oct 10;258(19):11689-93.
7
Simian sarcoma virus onc gene, v-sis, is derived from the gene (or genes) encoding a platelet-derived growth factor.猿猴肉瘤病毒癌基因v-sis源自编码血小板衍生生长因子的基因。
Science. 1983 Jul 15;221(4607):275-7. doi: 10.1126/science.6304883.
8
Human interferon-gamma is internalized and degraded by cultured fibroblasts.人γ干扰素被培养的成纤维细胞内化并降解。
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10
Interactions between the receptors for platelet-derived growth factor and epidermal growth factor.血小板衍生生长因子受体与表皮生长因子受体之间的相互作用。
J Cell Biol. 1983 Mar;96(3):679-83. doi: 10.1083/jcb.96.3.679.
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