血小板衍生生长因子受体与表皮生长因子受体之间的相互作用。
Interactions between the receptors for platelet-derived growth factor and epidermal growth factor.
作者信息
Bowen-Pope D F, Dicorleto P E, Ross R
出版信息
J Cell Biol. 1983 Mar;96(3):679-83. doi: 10.1083/jcb.96.3.679.
Abstract
Preincubation of Swiss 3T3 cells or human fibroblasts with purified platelet-derived growth factor (PDGF) at 4 degrees C or 37 degrees C rapidly inhibits subsequent binding of 125I-epidermal growth factor (125I-EGF). The effect does not result from competition by PDGF for binding to the EGF receptor since (a) very low concentrations of PDGF are effective, (b) cells with EGF receptors but no PDGF receptors are not affected, and (c) the inhibition persists even if the bound PDGF is eluted before incubating the cells with 125I-EGF. PDGF does not affect 125I-insulin binding nor does EGF affect 125I-PDGF binding under these conditions. Endothelial cell-derived growth factor also competes for binding to PDGF receptors and inhibits 125I-EGF binding. The inhibition demonstrated by PDGF seems to result from an increase in the Kd for 125I-EGF binding with no change in the number of EGF receptors.
摘要
在4℃或37℃下，用纯化的血小板衍生生长因子（PDGF）对瑞士3T3细胞或人成纤维细胞进行预孵育，可迅速抑制随后125I-表皮生长因子（125I-EGF）的结合。该效应并非由PDGF竞争结合EGF受体所致，因为：（a）极低浓度的PDGF即可产生作用；（b）具有EGF受体但无PDGF受体的细胞不受影响；（c）即便在用125I-EGF孵育细胞之前将结合的PDGF洗脱，抑制作用依然存在。在这些条件下，PDGF不影响125I-胰岛素的结合，EGF也不影响125I-PDGF的结合。内皮细胞衍生生长因子也竞争结合PDGF受体并抑制125I-EGF的结合。PDGF所显示的抑制作用似乎是由于125I-EGF结合的解离常数（Kd）增加，而EGF受体数量未变。
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