Chang Che-Mai, Wong Henry Sung-Ching, Huang Chien-Yu, Hsu Wen-Li, Maio Zhi-Feng, Chiu Siou-Jin, Tsai Yao-Ting, Chen Ben-Kuen, Wan Yu-Jui Yvonne, Wang Jaw-Yuan, Chang Wei-Chiao
Master Program for Clinical Pharmacogenomics and Pharmacoproteomics, School of Pharmacy, Taipei Medical University, Taipei 110, Taiwan.
Department of Clinical Pharmacy, School of Pharmacy, Taipei Medical University, Taipei 110, Taiwan.
Cancers (Basel). 2019 Apr 6;11(4):489. doi: 10.3390/cancers11040489.
MicroRNA regulation is crucial for gene expression and cell functions. It has been linked to tumorigenesis, development and metastasis in colorectal cancer (CRC). Recently, the family has been identified as a tumor suppressor in different types of cancers. However, the function of the family in CRC metastasis has not been fully investigated. Here, we focused on analyzing the role of in CRC. The Cancer Genome Atlas (TCGA) genomic datasets of CRC and detailed data from a Taiwanese CRC cohort were applied to study the expression pattern of . In addition, in vitro as well as in vivo studies have been performed to uncover the effects of on CRC. We found that the expression of was significantly lower in CRC specimens. Our results further supported the inhibitory effects of on CRC cell migration, invasion and extracellular calcium influx through store-operated calcium channels. We report a critical role for in the pathogenesis of CRC and suggest as a potential therapeutic target for CRC treatment.
微小RNA调控对于基因表达和细胞功能至关重要。它与结直肠癌（CRC）的肿瘤发生、发展和转移有关。最近，该家族已被确定为不同类型癌症中的肿瘤抑制因子。然而，该家族在CRC转移中的功能尚未得到充分研究。在这里，我们专注于分析其在CRC中的作用。应用CRC的癌症基因组图谱（TCGA）基因组数据集以及来自台湾CRC队列的详细数据来研究其表达模式。此外，还进行了体外和体内研究以揭示其对CRC的影响。我们发现其在CRC标本中的表达显著降低。我们的结果进一步支持了其通过储存操纵性钙通道对CRC细胞迁移、侵袭和细胞外钙内流的抑制作用。我们报告了其在CRC发病机制中的关键作用，并建议将其作为CRC治疗的潜在治疗靶点。
