CNRS, INCIA, UMR 5287, F-33000 Bordeaux, France.
University of Bordeaux, INCIA, UMR 5287, F-33000 Bordeaux, France.
Int J Mol Sci. 2019 Apr 7;20(7):1721. doi: 10.3390/ijms20071721.
Neurotensin and its high-affinity receptor, NTR₁, are involved in the growth of various tumors. Few data are available regarding NTR₁ expression in normal and tumoral human prostate tissue samples. NTR₁ expression was assessed using immunohistochemistry in 12 normal prostate tissues, 11 benign prostatic hyperplasia (BPH), 44 prostate cancers, and 15 related metastatic lymph nodes (one per patient, when available). NTR₁-staining was negative in normal prostate and BPH samples. NTR₁ was overexpressed in four out of 44 (9.1%) primary tumors. There was no clear association between NTR₁ overexpression and age, PSA-values, Gleason score, pT-status, nodal-status, or margin. NTR₁ was expressed at a high level of five out of 15 (33.3%) metastatic lymph nodes. NTR₁ overexpression was thus more frequent in metastatic lymph nodes than in primary tumors ( = 0.038). In this limited series of samples, NTR₁ overexpression was observed in few primary prostate cancers. Upregulation was more frequent in related lymph nodes. The presence of this target in metastatic lymph nodes may open new perspectives for imaging and radionuclide therapy of prostate cancer. Factors driving NTR₁ expression in primary prostate cancer and in nodal and distant metastases still need to be characterized.
神经降压素及其高亲和力受体 NTR₁ 参与多种肿瘤的生长。关于神经降压素在正常和肿瘤性人前列腺组织样本中的表达，仅有少量数据。使用免疫组织化学法评估了 12 例正常前列腺组织、11 例良性前列腺增生 (BPH)、44 例前列腺癌和 15 例相关转移性淋巴结 (当有条件时，每位患者 1 例) 中 NTR₁ 的表达。正常前列腺和 BPH 样本中 NTR₁ 染色呈阴性。在 44 例原发性肿瘤中有 4 例 (9.1%) 过度表达 NTR₁。NTR₁ 过表达与年龄、PSA 值、Gleason 评分、pT 分期、淋巴结分期或切缘无明显相关性。在 15 例转移性淋巴结中有 5 例 (33.3%) 表达高水平的 NTR₁。因此，转移性淋巴结中 NTR₁ 过表达的频率高于原发性肿瘤 ( = 0.038)。在这组有限的样本中，在少数原发性前列腺癌中观察到 NTR₁ 过表达。在上调中更频繁地观察到相关淋巴结。该靶标在转移性淋巴结中的存在可能为前列腺癌的成像和放射性核素治疗开辟新的前景。仍需确定驱动原发性前列腺癌以及淋巴结和远处转移中 NTR₁ 表达的因素。
